bioskills-combinatorial-screens

name	bioskills-combinatorial-screens
description	Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs.
domain	single-cell
primary_tool	MAGeCK
methods	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring"]
macro_tags	["combinatorial-crispr","genetic-interaction","synthetic-lethal","paralog-buffering","screen-analysis"]
micro_tags	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring","library-design","architecture-selection","singleton-controls","cas12a","qc","library-skew","gini","singleton-verification","coverage","interaction-terms","design-matrix","cas9","cassette-aggregation","lfc","synthetic-lethal","synthetic-rescue","additive-null","zscore","failure-diagnosis","validation","saturation","cross-modality","quality-control"]
source	bioskills-combinatorial-screens
status	active
enabled	true

Bioskills Combinatorial Screens