gsDesignNB

Design, simulate, and adapt clinical trials with negative binomial recurrent event endpoints using the gsDesignNB R package. Use this skill when the task involves: NB sample size or power, event gaps and Jensen correction, calendar-time group sequential design, blinded or unblinded information estimation, sample size re-estimation (SSR), recurrent-event simulation (constant or seasonal rates), interim data cuts, completer-based analyses, or non-inferiority/super-superiority designs for recurrent events.

Route gsDesignNB simulation requests to the right package functions and vignettes. Use when working on recurrent-event simulation, group sequential simulation, sample size re-estimation, blinded information, or when the user needs help choosing between nb_sim, sim_gs_nbinom, sim_ssr_nbinom, and related workflows.