القائمة
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
التثبيت باستخدام Codex أو Claude انسخ هذا Prompt والصقه في Codex أو Claude أو مساعد آخر ليراجع صفحة Skill ويثبّتها لك.
استنادا إلى تصنيف SOC المهني
Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Note: Guppy is deprecated; use Dorado for all new analyses.
Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis planning, report generation, and reproducibility export.
Ancestry decomposition PCA against the Simons Genome Diversity Project
Shotgun metagenomics profiling — taxonomy, resistome, and functional pathways
Semantic Similarity Index for disease research literature using PubMedBERT embeddings
Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels
| name | genome-compare |
| description | Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture |
| version | 0.1.0 |
| author | Manuel Corpas |
| license | MIT |
| tags | ["genome-comparison","IBS","ancestry","PGP","admixture"] |
| metadata | {"genetind":{"requires":{"bins":["python3"],"env":[],"config":[]},"always":false,"emoji":"🧬","homepage":"https://github.com/ClawBio/ClawBio","os":["macos","linux"],"install":[],"trigger_keywords":["genome comparison","IBS","identity by state","George Church","Corpasome","pairwise"]}} |
You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.
| Format | Extension | Required Fields | Example |
|---|---|---|---|
| 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | data/manuel_corpas_23andme.txt.gz |
George Church (hu43860C) — the first participant in the Personal Genome Project. Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in data/george_church_23andme.txt.gz.
.txt.gz)report.md with summary, IBS analysis, ancestry composition, and methods# Demo: Manuel Corpas vs George Church
python skills/genome-compare/genome_compare.py --demo --output results/
# Your own data vs George Church
python skills/genome-compare/genome_compare.py --input your_23andme.txt --output results/
# Via ClawBio runner
python clawbio.py run compare --demo
python clawbio.py run compare --input <file> --output <dir>
python clawbio.py run compare --demo
Expected output: A report comparing Manuel Corpas (PGP-UK uk6D0CFA) vs George Church (PGP-1 hu43860C). IBS score ~0.74 (consistent with two unrelated Europeans). Ancestry estimates for both individuals. Four figures generated.
output_directory/
├── report.md # Full comparison report
├── result.json # Machine-readable IBS and ancestry data
├── figures/
│ ├── chromosome_ibs.png # Per-chromosome IBS bar chart
│ ├── ancestry_pie.png # Ancestry composition pie chart
│ ├── ibs_context.png # IBS score on relationship spectrum gauge
│ └── ancestry_comparison.png # Side-by-side ancestry comparison
└── reproducibility/
└── commands.sh # Exact command to reproduce
Required:
numpy >= 1.24matplotlib >= 3.7Trigger conditions — the orchestrator routes here when:
Chaining partners:
claw-ancestry-pca: More detailed ancestry analysis with SGDP reference panelprofile-report: Genome comparison results feed into the unified genomic profile