rctd-py

GPU-accelerated Python RCTD cell type deconvolution for spatial transcriptomics (Visium, VisiumHD, Xenium, MERFISH, Slide-seq). Use when running rctd-py, when a Python alternative to R spacexr is needed, when deconvolving spatial data on GPU, when preparing h5ad references from Seurat/scanpy/CELLxGENE, or when integrating rctd-py results back into a Seurat/AnnData workflow. Covers the CLI (`rctd run`, `rctd validate`, `rctd info`), the Python API (`run_rctd`, `Reference`, `RCTDConfig`), all three modes (doublet / multi / full), GPU dtype selection, per-arch eigh tuning, and result interpretation. Triggers on "rctd-py", "python rctd", "GPU RCTD", "spacexr python", "h5ad deconvolution", "spatial cell type deconvolution python", "convert spacexr reference to h5ad".