// For working with any terms in the catalytic activity branch; these often correspond to RHEA or EC terms
Use the /research skill when performing background research from the literature or the web to create a RESEARCH.md file; also covers use of `deep-research-client`
For working with any terms referencing chemical entities (CHEBI). CHEBI has some unusual properties that are counter-intuitive, so always use this skill to plan or check work that involves a chemical entity or CHEBI IDs, whether a new term, or significant alteration of existing terms
Use this skill when planning to create new ontology terms or modify existing ones to ensure proper design pattern compliance. This skill should be used proactively during issue planning to identify appropriate design patterns before term creation begins. No intersection_of tags should be added without using this skill.
Use this to search for relevant terms in external ontologies. NEVER guess ontology terms or term IDs, always confirm using this skill. The general methodology is to use `obo-grep.pl`
For working with mappings (dbxrefs) in GO.
For working with GO taxon constraints (TCs), i.e never_in_taxon and only_in_taxon relationships
| name | reaction |
| description | For working with any terms in the catalytic activity branch; these often correspond to RHEA or EC terms |
Reaction terms may have mappings that are qualified using skos (using source qualifiers), as in the following:
[Term]
id: GO:0000140
name: acylglycerone-phosphate reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hexadecanoyl-sn-glycero-3-phosphate + NADP+ = 1-hexadecanoylglycerone 3-phosphate + H+ + NADPH." [RHEA:17341]
synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT []
synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.101]
synonym: "acyldihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101]
xref: EC:1.1.1.101 {source="skos:exactMatch"}
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN {source="skos:exactMatch"}
xref: MetaCyc:RXN-15046 {source="skos:narrowMatch"}
xref: RHEA:17341 {source="skos:exactMatch"}
xref: RHEA:36175 {source="skos:narrowMatch"}
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28526" xsd:anyURI
Ideally there is a single source of truth for a reaction terms, which should be specified in the def xref