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bioskills-combinatorial-screens

Stars102

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UpdatedJuly 6, 2026 at 12:06

Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs.

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ai4nucleome

ai4nucleome/BioMaster

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Biological Scientists, All OtherLife, Physical, and Social Science Occupations·SOC 19-1029

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SKILL.md

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name	bioskills-combinatorial-screens
description	Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs.
domain	single-cell
primary_tool	MAGeCK
methods	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring"]
macro_tags	["combinatorial-crispr","genetic-interaction","synthetic-lethal","paralog-buffering","screen-analysis"]
micro_tags	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring","library-design","architecture-selection","singleton-controls","cas12a","qc","library-skew","gini","singleton-verification","coverage","interaction-terms","design-matrix","cas9","cassette-aggregation","lfc","synthetic-lethal","synthetic-rescue","additive-null","zscore","failure-diagnosis","validation","saturation","cross-modality","quality-control"]
source	bioskills-combinatorial-screens
status	active
enabled	true

Bioskills Combinatorial Screens

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name	bioskills-combinatorial-screens
description	Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs.
domain	single-cell
primary_tool	MAGeCK
methods	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring"]
macro_tags	["combinatorial-crispr","genetic-interaction","synthetic-lethal","paralog-buffering","screen-analysis"]
micro_tags	["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring","library-design","architecture-selection","singleton-controls","cas12a","qc","library-skew","gini","singleton-verification","coverage","interaction-terms","design-matrix","cas9","cassette-aggregation","lfc","synthetic-lethal","synthetic-rescue","additive-null","zscore","failure-diagnosis","validation","saturation","cross-modality","quality-control"]
source	bioskills-combinatorial-screens
status	active
enabled	true