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bioskills-motif-deviation

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UpdatedJuly 6, 2026 at 12:06

Compute per-sample/per-cell TF motif accessibility deviation z-scores with chromVAR (bulk, Signac, ArchR) and optionally refine TF activity with DecoupleR.

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ai4nucleome

ai4nucleome/BioMaster

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Software DevelopersComputer and Mathematical Occupations·SOC 15-1252

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SKILL.md

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name	bioskills-motif-deviation
description	Compute per-sample/per-cell TF motif accessibility deviation z-scores with chromVAR (bulk, Signac, ArchR) and optionally refine TF activity with DecoupleR.
domain	single-cell
primary_tool	chromVAR
methods	["chromVAR","motifmatchr","JASPAR2024","TFBSTools","SummarizedExperiment","limma","Signac","ArchR","decoupler"]
macro_tags	["workflow","motif-deviation","chromvar","tf-activity","atac"]
micro_tags	["chromVAR","motifmatchr","JASPAR2024","TFBSTools","SummarizedExperiment","limma","Signac","ArchR","decoupler","qc","filtering","gc-bias","summarized-experiment","motif-matching","jaspar","cisbp","chromvar","background-peaks","deviations","variability","differential","findmarkers","marker-features","tf-activity","consensus","multi-omics"]
source	bioskills-motif-deviation
status	active
enabled	true

Bioskills Motif Deviation

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name	bioskills-motif-deviation
description	Compute per-sample/per-cell TF motif accessibility deviation z-scores with chromVAR (bulk, Signac, ArchR) and optionally refine TF activity with DecoupleR.
domain	single-cell
primary_tool	chromVAR
methods	["chromVAR","motifmatchr","JASPAR2024","TFBSTools","SummarizedExperiment","limma","Signac","ArchR","decoupler"]
macro_tags	["workflow","motif-deviation","chromvar","tf-activity","atac"]
micro_tags	["chromVAR","motifmatchr","JASPAR2024","TFBSTools","SummarizedExperiment","limma","Signac","ArchR","decoupler","qc","filtering","gc-bias","summarized-experiment","motif-matching","jaspar","cisbp","chromvar","background-peaks","deviations","variability","differential","findmarkers","marker-features","tf-activity","consensus","multi-omics"]
source	bioskills-motif-deviation
status	active
enabled	true