syntheticgio/AIBioSkills

clinical-variant-agent

Full clinical variant workup — gnomAD population frequency, ClinVar significance, protein domain impact, AlphaFold structure context, and PubMed literature

comparative-genomics-agent

Compare a gene across multiple species — find orthologs, retrieve sequences, compute alignments, and summarize conservation

drug-target-report

Druggability assessment — protein function, 3D structures, ligand-bound PDBs, binding sites, interaction network, disease associations, and literature

gene-list-agent

Functional analysis of a gene list — batch summaries, pathway mapping, protein interactions, tissue expression, and phenotype associations

gene-report

Generate a comprehensive gene report by combining data from NCBI, Ensembl, UniProt, ClinVar, PDB, InterPro, STRING, and KEGG

lab-notebook

Research session lab notebook — start, annotate, update, report, or check status

literature-agent

Search PubMed for relevant biomedical literature on a gene, variant, disease, or topic and produce a structured literature summary

pathway-report

Generate a pathway deep-dive report combining Reactome pathway data, member gene summaries, ClinVar variants, and PubMed literature

project-summary

Summarize all MCP tools, capabilities, and usage examples for this project

protein-report

Generate a protein-centric report combining UniProt, InterPro, AlphaFold, PDB, STRING, and post-translational modification data

statistical-methods-agent

Fetch a biomedical research paper and produce a structured analysis of every statistical method used — including assumptions, plain-language interpretation, and critique

structure-agent

Structural biology deep-dive — all PDB structures, AlphaFold prediction, variant mapping onto structure, domain architecture, and literature

variant-report

Generate a variant annotation report combining Ensembl, ClinVar, and UniProt data for a gene or genomic region