postgwas-skills

Colocalization analysis workflow to assess whether two traits share the same causal variant. Use when user mentions colocalization, coloc, shared causal variant, co-localization, or wants to test if GWAS and QTL signals overlap.

Mendelian Randomization analysis workflow for causal inference from GWAS summary statistics. Use when user mentions MR, Mendelian randomization, causal inference, two-sample MR, IVW, MR-Egger, weighted median, or wants to estimate causal effect of exposure on outcome.