gsDesign

Choose the appropriate gsDesign survival or exact-binomial workflow when requests involve calendar-time interim analyses, event- or information-driven survival looks, seasonal rare-event exact-binomial monitoring, or explicit randomization ratios; covers when to use gsSurvCalendar(), gsSurv(), simBinomialSeasonalExact(), and toBinomialExact().

Build and document exact binomial group sequential designs with spending in gsDesign. Use when the user mentions toBinomialExact, gsBinomialExact, repeatedPValueBinomialExact, sequentialPValueBinomialExact, simBinomialSeasonalExact, vaccine/prevention efficacy with seasonal looks, or blinded information-based adaptation with fixed spending fractions.