database-lookup

name	database-lookup
description	Search 78 public scientific, biomedical, materials science, and economic databases via their REST APIs and return structured JSON results. Covers physics/astronomy (NASA, NIST, SDSS, SIMBAD, Exoplanet Archive), earth/environment (USGS, NOAA, EPA, OpenWeatherMap), chemistry/drugs (PubChem, ChEMBL, DrugBank, FDA, KEGG, DailyMed, ZINC, BindingDB), materials science (Materials Project, COD), biology/genomics (Reactome, BRENDA, UniProt, STRING, Ensembl, NCBI Gene, GEO, GTEx, PDB, AlphaFold, InterPro, ChEBI, BioGRID, Gene Ontology, QuickGO, NCBI Protein/Taxonomy, dbSNP, SRA, ENA, gnomAD, UCSC Genome, ENCODE, JASPAR, MouseMine, PRIDE, LINCS L1000, Human Protein Atlas, Human Cell Atlas, RummaGEO, Metabolomics Workbench, EMDB, Addgene), disease/clinical (COSMIC, Open Targets, ClinPGx, ClinicalTrials.gov, OMIM, ClinVar, GDC/TCGA, cBioPortal, DisGeNET, GWAS Catalog, Monarch, HPO), regulatory (FDA, USPTO, SEC EDGAR), economics/finance (FRED, BEA, BLS, Federal Reserve, World Bank, ECB, US Treasury, Alpha Vantage, Data Commons), and demographics (US Census, Eurostat, WHO). Use this skill whenever the user wants to look up compounds, drugs, proteins, genes, pathways, enzymes, gene expression, variants, clinical trials, patents, SEC filings, economic indicators, crystal structures, astronomical objects, earthquakes, weather, or any data from a public database API. Also trigger when the user mentions any database by name or asks about molecular properties, drug-target interactions, binding affinities, protein interactions, pathway membership, pharmacogenomics, economic time series, materials properties, commercially available compounds, virtual screening, compound purchasability, chemical libraries, building blocks, cancer genomics, somatic mutations, tumor mutation profiles, nucleotide sequences, genome assemblies, sequencing reads, ENA accessions, INSDC data, or wants to cross-reference entities across sources.
tags	["scientific-skills","database-lookup","api","cheminformatics","clinical","finance","react","database","bioinformatics","search","compliance"]
metadata	{"skill-author":"K-Dense Inc."}

|---| | Near-Earth objects, asteroids | NASA (NeoWs) | — | | Mars rover images | NASA (Mars Rover Photos) | — | | Exoplanets, orbital parameters | NASA Exoplanet Archive | — | | Astronomical objects by name/coordinates | SIMBAD | SDSS | | Galaxy/star spectra, photometry | SDSS | SIMBAD | | Physical constants | NIST | — | | Atomic spectra, spectral lines | NIST (ASD) | — |

Earth & Environmental Sciences

User is asking about...	Primary database(s)	Also consider
Earthquakes, seismic events	USGS Earthquakes	—
Water data, streamflow, groundwater	USGS Water Services	—
Weather (current, forecast, historical)	OpenWeatherMap	NOAA
Climate data, historical weather stations	NOAA (CDO)	—
Air quality, toxic releases	EPA (Envirofacts)	—

Chemistry & Drugs

User is asking about...	Primary database(s)	Also consider
Chemical compounds, molecules	PubChem	ChEMBL
Molecular properties (weight, formula, SMILES)	PubChem	—
Drug synonyms, CAS numbers	PubChem (synonyms)	DrugBank
Bioactivity data, IC50, binding assays	ChEMBL	BindingDB, PubChem
Drug binding affinities (Ki, IC50, Kd)	ChEMBL, BindingDB	PubChem
Drug-target interactions	ChEMBL, DrugBank	BindingDB, Open Targets
Ligands for a protein target (by UniProt)	BindingDB	ChEMBL
Target identification from compound structure	BindingDB (SMILES similarity)	ChEMBL
Drug labels, adverse events, recalls	FDA (OpenFDA)	DailyMed
Drug labels (structured product labels)	DailyMed	FDA (OpenFDA)
Drug pharmacology, indications	DrugBank	FDA
Chemical cross-referencing	PubChem (xrefs)