| name | tooluniverse-drug-drug-interaction |
| description | Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support. |
Drug-Drug Interaction Prediction & Risk Assessment
Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
KEY PRINCIPLES:
- Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively
- Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ)
- Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
- Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
- Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions
- Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate
When to Use This Skill
Apply when users:
- Ask about interactions between 2+ specific drugs
- Need polypharmacy risk assessment (5+ medications)
- Request medication safety review for a patient
- Ask "can I take drug X with drug Y?"
- Need alternative drug recommendations to avoid DDIs
- Want to understand DDI mechanisms
- Need clinical management strategies for known interactions
- Ask about QTc prolongation risk from multiple drugs
Critical Workflow Requirements
1. Report-First Approach (MANDATORY)
DO NOT show intermediate tool outputs or search processes. Instead:
-
Create report file FIRST - Before any data collection:
- File name:
DDI_risk_report_[DRUG1]_[DRUG2].md (or _polypharmacy.md for 3+)
- Initialize with all 9 section headers
- Add placeholder:
[Analyzing...] in each section
-
Progressively update - As data is gathered:
- Replace
[Analyzing...] with findings
- Include "No interaction detected" when tools return empty
- Document failed tool calls explicitly
-
Final deliverable - Complete markdown report with recommendations
[... Content continues as above for full 500+ lines ...]
Success Criteria
Before finalizing DDI report:
✅ All drug names resolved to standard identifiers
✅ Bidirectional analysis completed (A→B and B→A)
✅ All mechanism types assessed (CYP, transporters, PD)
✅ FDA label warnings extracted
✅ Clinical literature searched
✅ Evidence grades assigned (★★★, ★★☆, ★☆☆)
✅ Risk score calculated (0-100)
✅ Severity classified (Major/Moderate/Minor)
✅ Primary management recommendation provided
✅ Alternative drugs suggested
✅ Monitoring parameters defined
✅ Patient counseling points included
✅ All sections completed (no [Analyzing...] placeholders)
✅ Data sources cited throughout
When all criteria met → Ready for Clinical Use 🎉
