| name | alphafold-fetch |
| description | Fetch and analyze AlphaFold-predicted protein structures from the AlphaFold DB or EBI. |
AlphaFold Fetch
Retrieve and evaluate AlphaFold structures for target proteins.
Commands
| Command | Description |
|---|
web_search "site:alphafold.ebi.ac.uk <uniprot-id>" | AlphaFold DB entry |
web_search "AlphaFold <protein-name> structure" | Search for structure |
Evaluation Criteria
- pLDDT score:
-
90: very high confidence (backbone correct)
- 70-90: confident (correct fold)
- 50-70: low confidence (may have wrong fold)
- <50: very low confidence (unstructured/disordered)
- PAE matrix: Check domain-domain confidence
- Disordered regions: pLDDT < 50
- Ligand binding pockets: Compare with experimental structures if available
Output
# AlphaFold Structure: [protein]
## UniProt ID: ...
## pLDDT Distribution
| Domain/Region | Residues | Mean pLDDT | Confidence |
## Structural Features
- Domains
- Disordered regions
- Known binding sites
- Comparison with PDB structures
## Recommendations
- Suitability for docking
- Suitability for MD simulation
- Regions requiring experimental validation
Save to outputs/alphafold-<slug>.md.