// Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence.
Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.
Query or inspect the FDA Orange Book - FDA-Approved Drug Products Listing resource for drug-centric tasks with emphasis on drug knowledgebase Use whenever Codex needs the calling pattern, downloadable entrypoint, or example query flow from this skill example script.
Query the RepurposeDrugs single-agent drug repurposing database. Use whenever the user asks about drug-disease repurposing associations, clinical trial phases for repurposed drugs, or wants to look up any entity (drug name, disease name, NCT ID) in RepurposeDrugs.
Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.
Query canonical TarKG drug-target triplets. Use when the user asks about drug-target interactions, relation labels, disease/pathway context, or quick lookups for drugs/targets in TarKG.
Query the MecDDI mechanism-based drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI mechanisms (PK/PD), enzyme or transporter-mediated interactions, or wants to look up interacting drug pairs by drug name or MecDDI drug ID. Trigger on keywords like DDI, drug interaction, MecDDI, mechanism-based interaction, pharmacokinetic interaction, pharmacodynamic interaction, or any query involving two drugs that may interact.
| name | drugcombdb-query |
| description | Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence. |
Query canonical packaged DrugCombDB CSV rows.
resources_metadata/drug_combination/DrugCombDB/drugcombdb.csvDrug1, Drug2, Cell, Synergy, SynergyType, PMID| Function | Input | Returns |
|---|---|---|
load_data(path) | CSV path | list[dict] |
search_drug(drug_name, limit) | drug name | list[dict] |
search_cell_line(cell, limit) | cell line | list[dict] |
search_drug_pair(drug1, drug2, limit) | drug pair | list[dict] |
search(entity, limit) | free text | list[dict] |
search_batch(entities, limit) | list of strings | dict[str, list[dict]] |
summarize(results, entity) | rows + label | compact text |
Run example.py directly for canonical-path demos.