Search arXiv for preprints in physics, math, CS, quantitative biology, quantitative finance, statistics, electrical engineering, economics. Use when: (1) finding preprints by topic, (2) searching by author, (3) browsing arXiv categories, (4) getting paper metadata/abstracts. NOT for: published journal articles (use crossref-search), biomedical (use pubmed-search).

2026-03-12850

asreview-screening

beita6969/ScienceClaw

Screen papers for systematic reviews using ASReview active learning. Use when: user has a large set of papers to screen for inclusion/exclusion, wants to prioritize relevant papers, or needs to reduce manual screening workload. NOT for: searching papers (use literature-search) or meta-analysis (use meta-analysis).

2026-03-12850

astronomy-cosmology

beita6969/ScienceClaw

Analyzes astronomical observations and cosmological models including telescope data processing, celestial mechanics calculations, stellar evolution, galaxy classification, and cosmological parameter estimation; trigger when users discuss stars, galaxies, exoplanets, dark matter, or the universe's large-scale structure.

2026-03-12850

astropy-astronomy

beita6969/ScienceClaw

"Astronomical computations via Astropy. Use when: user asks about celestial coordinates, FITS files, or cosmological calculations. NOT for: telescope control or real-time observation planning."

2026-03-12850

bioinformatics

beita6969/ScienceClaw

Performs bioinformatics analyses including pathway enrichment, gene ontology analysis, protein-protein interaction networks, multi-omics integration, and biological sequence database querying; trigger when users discuss gene sets, biological pathways, functional annotation, or omics data integration.

2026-03-12850

name	clinical
description	null

Clinical Research

Overview

Clinical study design, statistical analysis, and regulatory compliance for medical research.

Study Designs

Design	Level of Evidence	Best For
RCT	I	Treatment efficacy
Cohort (prospective)	II	Risk factors, prognosis
Cohort (retrospective)	III	Exposure-outcome associations
Case-control	III	Rare diseases, risk factors
Cross-sectional	IV	Prevalence, correlations
Case report/series	V	Novel observations

Common Analyses

Survival analysis: Kaplan-Meier curves, Log-rank test, Cox regression
Diagnostic accuracy: Sensitivity, specificity, ROC curve, AUC
Meta-analysis: Fixed/random effects, forest plot, heterogeneity (I-squared)
Propensity score matching: For observational study confounding
Nomogram: Predictive model visualization for clinical use

Sample Size Calculation

Define: alpha (usually 0.05), power (usually 0.80), effect size, outcome type
Tools: G*Power, R pwr package, Python statsmodels
Report: formula used, assumptions, expected dropout rate

Regulatory Compliance

IRB/Ethics committee: Required for all human subjects research
Informed consent: Written, voluntary, comprehensive
ClinicalTrials.gov: Registration before enrollment (ICMJE requirement)
GDPR/HIPAA: Data privacy for patient information
GCP (Good Clinical Practice): ICH E6 guidelines

Reporting Guidelines

Guideline	Study Type
CONSORT	Randomized controlled trials
STROBE	Observational studies
PRISMA	Systematic reviews / meta-analyses
STARD	Diagnostic accuracy
TRIPOD	Prediction models
SPIRIT	Study protocols