JimLiu

Predict protein structure for monomers and multimers with AlphaFold2 via the ColabFold runner (Mirdita et al. 2022, github.com/sokrypton/ColabFold; AlphaFold2 Jumper et al. 2021). Reach for this skill to fold a sequence or complex with the AF2/AF2-Multimer…

Structure prediction for protein, nucleic-acid, and small-molecule complexes with Boltz-2 (Passaro & Wohlwend et al. 2025, github.com/jwohlwend/boltz). Reach for this skill to validate designed binders against a target, to co-fold a protein with a SMILES or…

Predict genome-wide functional tracks (RNA-seq, CAGE, DNase, ChIP) from DNA sequence with Borzoi. Use this skill when: (1) Scoring the regulatory effect of a variant on expression/accessibility, (2) Generating predicted coverage tracks for a locus, (3)…

Structure prediction for protein, nucleic-acid, and small-molecule complexes with the Chai-1 foundation model (Chai Discovery 2024, github.com/chaidiscovery/chai-lab). Reach for this skill to predict an antibody-antigen or protein-ligand complex from a single…

Set up a compute environment on a remote provider so Claude Science jobs can run there. Covers direct SSH/conda hosts, Slurm clusters, container-via-bridge runners, and managed-API providers (Modal, GCP, RunPod). Use when standing up a new provider, porting…

Create, configure, and maintain custom agent profiles and author new skills via the `repl` tool. Use when the user wants to create an agent profile, build a custom agent, modify agent capabilities, attach or detach skills/connectors on a profile, author a…

Predict small-molecule binding poses with DiffDock-L (Corso et al. 2023/2024, github.com/gcorso/DiffDock) — blind diffusion docking that places a ligand into a protein pocket without a predefined search box and ranks the samples with a learned confidence…

Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the…

把历史录音、演讲、访谈、广播或档案影像做成观众看得懂的成片：先用几分钟讲清这个人、那个时代、这次讲话为什么要紧，再放完整的原声（原文与译文字幕、分章节）。讲法与画面由手上的材料定（只有录音还是有影像、照片多少、单语还是双语），不套模板；当时的照片、新闻片、报刊、地图与当事人的原声优先，生成的图只画没有真人的示意。只给录音配字幕、排版面走 subtitle-workflow；讲一个历史话题、没有一段要完整放的原声时走 explainer-video 或 clip-montage。

从零做一条完整成片时用：推广短片、知识讲解、故事短片、发布片、资讯快评、数据故事、排版动效、歌曲 MV 与歌词视频，或用户选了场景模板、作品示例说「做一条视频」。简报定下后，先写风格与角色设定、分镜与声音规划，再出参考图，逐镜用素材、生成图片或代码画面做出来，配旁白、混音、导出验收。只转录、加字幕、翻译、配音或剪已有视频时不用。

用 BaoCut 处理视频与音频：转录、字幕、翻译、配音、剪口播、切短视频、分章、总结写稿、从链接下载、压缩转码、导出成片，或从零做一条成片。有媒体文件、视频链接、字幕文件或 BaoCut 视频时用；只翻译纯文本、与视频无关的写作或作图、别的剪辑器与 FFmpeg 的用法、BaoCut 源码开发不用。

给音频视频定制内容背景与标题，或要在视频上加一段动效图形时用：下横栏（姓名职务）、关键词字幕、大数字与图表、标注与引导、品牌贴片与片尾、倒计时与进度。不选模板，按规则写一个自包含的 HTML 画面（时间的纯函数），打包成代码包导入后放上时间线。只加静态文字、贴纸或已有的文字动画预设时不用；声波一律用内置的声波元素，不用本 skill 画；整条成片的规划看「从简报到成片」。

有命令行环境、旁白按段配、画面按段上时间线的片子（讲解、解说混剪、旁白片、歌词视频……）要跑脚本时用：配音、对齐字时间、把场景代码打成代码包、按段摆上时间线并处理变长变短的波纹、按稿子建字幕、剪实拍与水印叠上去或垫在底下、量画面占比。脚本是一条省事的路，不规定片子的形态；形态和它不合时用 baocut CLI 自己写。只是加一段动效图形或配一句旁白时不用。

做知识讲解、科普、教学类视频时读的手艺页：把一个概念、一条新闻、一篇论文或一份资料，讲成没有背景的人也看得懂、愿意看完、看完能复述。给的是判断与手法，不是模板与流程：从观众的疑问找讲法，给这期找一个贯穿全片、自己会讲道理的主体，画面与旁白由同一份事实驱动，核实事实，像审片人一样看一遍；每一版交付成片、封面图与发布稿。制作照 video-production 与 narration。分步操作教程、剪口播不用。

做一条由旁白带着走的成片（资讯快评、知识讲解、产品介绍、步骤教程），或给已有画面配一段多句的旁白时用：先按实测语速算出稿子该有多少字、按句分行写稿，再选一个全片不变的音色、用同一套语气说明一次合成，量时长、查接缝、只重配不合格的句子，最后把画面剪到旁白上。不用于把视频配成另一种语言（翻译配音），也不用于只念一句话。

用户给了视频链接或本机音视频，要转录、加字幕、做译文字幕或双语字幕时用：建可编辑视频并导入，转写、润色，需要时翻译，把字幕层放到画面上，再按需导出字幕文件或成片。有媒体时「转录」「加字幕」「翻译成某种语言」都按这个流程。不用于与视频无关的文字翻译。

AI image generation with OpenAI GPT Image 2.5, Azure OpenAI, Google, OpenRouter, DashScope, Z.AI GLM-Image, MiniMax, Jimeng, Seedream, Replicate and Agnes APIs. Supports text-to-image, reference images, aspect ratios, and batch generation from saved prompt…

Fetch any URL and convert to markdown using baoyu-fetch CLI (Chrome CDP with site-specific adapters). Built-in adapters for X/Twitter, YouTube transcripts, Hacker News threads, and generic pages via Defuddle. Handles login/CAPTCHA via interaction wait modes.…

Summarizes WeChat group chat highlights into a structured digest using the local wx-cli binary (https://github.com/jackwener/wx-cli). Generates a normal digest by default; a roast (毒舌) version is opt-in. Maintains per-group history (history.json +…

Posts content and articles to X (Twitter). Supports regular posts with images/videos and X Articles (long-form Markdown). In Codex, honor explicit requests for the Codex Chrome plugin/@chrome by using the Chrome Extension workflow; otherwise use Chrome…

Generates images and text via reverse-engineered Gemini Web API. Supports text generation, image generation from prompts, reference images for vision input, and multi-turn conversations. Use when other skills need image generation backend, or when user…

Posts content to WeChat Official Account (微信公众号) via API or Chrome CDP. Supports article posting (文章) with HTML, markdown, or plain text input, and image-text posting (贴图, formerly 图文) with multiple images. Markdown article workflows default to converting…

This skill should be used when the user asks to "translate", "翻译", "精翻", "translate article", "translate to Chinese", "translate to English", "改成中文", "改成英文", "convert to Chinese", "localize", "本地化", "refined translation", "精细翻译", "proofread translation",…

Analyzes article structure, identifies positions requiring visual aids, generates illustrations with Type × Style × Palette three-dimension approach. Use when user asks to "illustrate article", "add images", "generate images for article", or "为文章配图".

把任何输入的信息快速转化为简洁、易懂的中文资讯，让读者一两分钟抓住要点。 适用于新闻、报道、长文、研究报告、论文、政策文件、产品资料、官方博客、链接等各类信息。 当用户提供一段内容（尤其是英文/外文，或较长、较专业的材料），或贴出链接、标题，要求 "整理成中文资讯""写成快讯/速递/简报""用大白话讲讲""帮我把这个讲清楚""划个重点"时使用。 即使用户没明确说"写简报"，只要意图是把信息转述成给中文读者看的简短、好懂版本，也应触发。…

多轮对抗式稿件打磨技能。通过"批评→改写→综合→盲评"循环，像学术同行评审一样反复打磨稿件直到收敛。所有中间产物（批评、改写、综合、评分）保存为独立文件，完整记录进化过程。当用户说"对抗打磨""反复打磨""深度打磨""多轮润色""盲评打磨""打磨到收敛""帮我把这篇稿子磨一磨""pressure polish""adversarial polish"时触发。也适用于用户说"这篇稿子很重要，帮我好好打磨"或"我需要更高质量的润色"等暗示需要超越单轮润色的场景。注意：如果用户只是要求普通润色，优先使用已有…

素材深度分析技能。当用户提供文章、推文、视频文稿等内容并要求分析时使用。 适用于：(1) 理解素材核心观点和论证逻辑，(2) 批判性评估内容，(3) 为后续写作提取可用素材， (4) 分析内容的传播价值。支持长文、短内容（推文/帖子）、视频文稿等多种内容类型。

分析播客/视频访谈内容，提取高价值信息点、金句、待验证背景， 并生成详细写作提纲。当用户提供访谈转录稿或整理稿，需要进行内容分析、 素材提取、或准备写作提纲时使用此 skill。

将播客/视频访谈的分析素材转化为访谈实录整理文章。按访谈原始 顺序组织，保留问答结构的对话感，补充背景解读，让读者通过文字快速了解 访谈全貌。当用户已完成访谈内容分析（有素材包和提纲），需要撰写正式文章 时使用此 skill。

科技专栏提纲生成技能。当用户提供素材（文章、推文、视频文稿等） 要求生成写作提纲时使用。生成 3-5 个差异化大纲方案（优先包含故事驱动型）， 每个方案保存独立文件供用户选择。

生成中文周报（Markdown 表格格式）。当用户提到"周报""写周报""本周工作""weekly report"或描述本周完成的工作内容时触发。即使用户只是随意列出这周做了什么，也应该触发这个技能来帮忙整理成周报。

《图解 Skill —— AI 提效实战指南》专用配图技能。分析本书章节、附录或书稿内容，批量识别需要视觉辅助的位置，并行生成本书统一风格的插图提示词，批量出图，最后回写书稿。 当用户要求"为本书配图"、"给本书章节生成插图"、"补画书中插图"、"重画本书配图"、"生成章节信息图"时使用此技能。 不用于普通文章、营销图、社媒图或其他书籍的通用配图任务。

Make and revise designs in the Design (canvas) artifact format (project/canvas.json plus one .dc.html Design Component file per artboard) as local files, then open them in a local canvas editor where the user can view the artboards side by side, retype copy…

Use this for a local, data-backed dashboard, metrics page, KPI tracker, scorecard, data visualization or recurring report that opens in the bundled live editor: a page or scroll story of charts, numbers and tables over datasets (a CSV/TSV/JSON file the user…

Create and revise design systems in the Design System artifact format (project/design-system.json, tokens.json, a README brand book, component previews, fonts and asset groups) as local files, then open them in a local design-system page where the user can…

Create or edit visual design artifacts as self-contained HTML: UI mockups, interactive prototypes, wireframes, landing pages, dashboards, app screens, slide decks, print documents, résumés, animations, 3D objects, diagrams, fliers, HTML email, and visual…

Make and revise slide decks in the Slides artifact format (project/deck.json plus one HTML file per slide) as local files, then open them in a local slide editor where the user can present, retype, drag, and export PDF, HTML or PowerPoint. Use when the user…

Reverse-engineer minified, obfuscated, packed, or bundled JavaScript into readable or typed TS/TSX, including Codex.app `./ref/webview/assets` restoration. Use for .min.js, dist bundles, Vite/Rollup/Webpack chunks, obfuscated snippets, or requests to…

Refresh the local ChatGPT app reference source from the installed macOS ChatGPT.app asar. Use when Codex needs to get the latest installed ChatGPT app code, recreate ./ref from /Applications/ChatGPT.app/Contents/Resources/app.asar, or format extracted…

Async audio/video understanding with Doubao-Seed (火山方舟 Ark). Handles ASR (plain / per-character timestamps / multispeaker), AST translation, speaker diarization, subtitle alignment, audio-visual captioning, video timeline JSON, technical-blog keyframe…