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Workflow for proposing new METPO terms from KG-Microbe transform output. Use when adding new METPO classes or properties, drafting an upstream submission to berkeleybop/metpo, or validating a proposal before sharing with curators.
Codex または Claude でインストール この Prompt をコピーして Codex、Claude、または他のアシスタントに貼り付けると、Skill ページを確認してインストールできます。
SOC 職業分類に基づく
Knowledge modeling review of KG-Microbe transforms and merged KG for alignment with METPO, Biolink Model, and KGX specification. Use when auditing transform output quality, validating categories/predicates, checking CURIE prefix registration, or preparing a release.
Add a new data source transform to KG-Microbe end-to-end — from "should we even ingest this?" through deep research, cross-reference analysis, semantic design, code scaffold, integration, verification, and shipping the PR. Bakes in the CLAUDE.md 7-step checklist plus the research + analysis + verify phases that keep the KG coherent. Use whenever the ask is "ingest X", "add source Y", or "integrate a new database into kg-microbe".
Ship a messy topic branch as a set of clean, focused PRs. Walks through triage of committed commits + working-tree modifications + untracked files, extracts misfiled commits to their own branches, splits orthogonal changes into separate PRs, gitignores build noise, opens follow-up issues for deferred items, and merges in the correct dependency order. Use when a working branch has accumulated mixed commits, uncommitted work, and dozens of untracked scratch files and needs to reach master.
Emit a Codex-ready review prompt for the KG-Microbe repository focused on code logic, consistency, robustness, bugs, bottlenecks, and scalability. Use before delegating a deep review pass to Codex (via the codex:rescue subagent) or another external code-review agent so the target is precisely scoped and the review dimensions are enforced.
Determine whether local KG-Microbe transform outputs (data/transformed/<source>/) and merged KG (data/merged/) are current relative to origin/master. Compares latest commit times on origin/master touching each transform's code directory against local output mtimes; also checks merge stage against merge_utils/, merge.yaml, and every transform output. Use before cutting a release, before running kg-release, or when triaging "why did my merged KG change".
Work with KG-Microbe's unified chemical mapping system (`mappings/kgmicrobe_unified_entity_mappings.sssom.tsv.gz` and `kg_microbe/utils/chemical_mapping_utils.py`). Use when adding a new mapping source, regenerating the unified file, debugging a missing ChEBI lookup, validating mappings against OLS, or reasoning about which source wins when sources disagree.
| name | metpo-proposal |
| description | Workflow for proposing new METPO terms from KG-Microbe transform output. Use when adding new METPO classes or properties, drafting an upstream submission to berkeleybop/metpo, or validating a proposal before sharing with curators. |
Produce a clean, ROBOT-validated, ELK-coherent METPO term proposal that can be filed against berkeleybop/metpo. A proposal must:
<genus>: <differentia>).IAO:0000119 axiom annotation).METPO:1000000 when a sibling parent exists).robot template ingestion and robot reason --reasoner ELK without unsatisfiable classes.oboInOwl:inSubset) so curators can filter by proposal cohort.| File | Format | Role |
|---|---|---|
mappings/metpo_proposal_categorical.tsv | curation TSV (one header) | Human-edited proposal of categorical classes; emitted by scripts/extract_metpo_proposals.py |
mappings/metpo_proposal_quantitative.tsv | curation TSV | Datatype properties + numeric tolerance class forms |
mappings/metpo_existing_aliases.tsv | curation TSV | Proposed concepts that already exist in METPO (use these IDs instead) |
mappings/metpo_label_corrections.tsv | curation TSV | Upstream label-fix requests for existing METPO terms whose rdfs:label disagrees with their numeric-threshold or other intrinsic synonyms. Each row cites a berkeleybop/metpo issue. Distinct from metpo_existing_aliases.tsv: aliases route a kg-microbe-side label to an existing METPO ID as-is; corrections request that the upstream record itself be amended. |
mappings/metpo_proposal_classes_robot.tsv | ROBOT template (two header rows) | Class declarations submittable to METPO maintainers |
mappings/metpo_proposal_properties_robot.tsv | ROBOT template | Property declarations submittable to METPO maintainers |
kg_microbe/transform_utils/metatraits/mappings/metpo_alias_mappings.tsv | Tier-2 override | Consumed by metatraits transform to use existing METPO IDs |
mappings/kgmicrobe_proposal_placeholders.tsv | curation TSV | Registry of kgmicrobe.*:* placeholder CURIEs that transforms emit while a METPO term is still under proposal — see "Placeholder policy" below |
The *_robot.tsv files are the upstream-submittable artifacts. The plain metpo_proposal_*.tsv files are the curation/audit ledger.
Until a proposed METPO term is officially minted in the upstream
berkeleybop/metpo release, KG-Microbe transforms MUST NOT emit the proposed
METPO ID into nodes.tsv / edges.tsv. Instead the transform mapping points at
a kgmicrobe.<sub>:<local_id> placeholder CURIE.
kg_microbe/transform_utils/custom_curies.yaml under one of the
kgmicrobe.activity / kgmicrobe.trait / kgmicrobe.compound /
kgmicrobe.pathway blocks.mappings/kgmicrobe_proposal_placeholders.tsv. Every kgmicrobe.* CURIE that
does correspond to a row in mappings/metpo_proposal_*.tsv MUST be listed
there with status, used_by, and target proposed_metpo_id.When a proposal lands upstream and the METPO ID is minted, swap the
transform-side object_id from the kgmicrobe.* placeholder back to the METPO
ID and update status=accepted in the placeholder registry.
poetry run python scripts/extract_metpo_proposals.py
This:
data/transformed/ontologies/metpo_nodes.tsv (no label/synonym collisions).data/raw/bacdive_strains.json if present (data-driven check, see compute_bacdive_observations).Run poetry run pytest tests/test_extract_metpo_proposals.py to confirm regenerate-and-diff cleanliness (artifact-as-source-of-truth gate).
After editing the curation TSVs, regenerate the ROBOT-shaped tables. Two header rows are required: row 1 is the human-readable column name; row 2 is the ROBOT directive.
Classes (metpo_proposal_classes_robot.tsv):
| Column | Directive | Effect |
|---|---|---|
proposed_id | ID | subject IRI |
label | LABEL | rdfs:label |
definition | A IAO:0000115 | textual definition annotation |
definition_source | >A IAO:0000119 | axiom annotation on the definition (proper OBO citation pattern) |
parent | SC % | rdfs:subClassOf |
synonyms | A oboInOwl:hasExactSynonym SPLIT=| | exact synonyms (pipe-split) |
xrefs | A oboInOwl:hasDbXref SPLIT=| | dbxrefs (pipe-split) |
subset | A oboInOwl:inSubset | proposal cohort tag (e.g. metpo_proposal_2026_04) |
priority, observations, traits_addressed | (empty) | curation metadata, ignored by ROBOT |
Properties (metpo_proposal_properties_robot.tsv):
| Column | Directive | Effect |
|---|---|---|
proposed_id | ID | subject IRI |
label | LABEL | rdfs:label |
definition | A IAO:0000115 | definition |
definition_source | >A IAO:0000119 | citation |
type | TYPE | owl:DatatypeProperty or owl:ObjectProperty |
domain | DOMAIN | rdfs:domain |
range | RANGE | rdfs:range |
xrefs | A oboInOwl:hasDbXref SPLIT=| | dbxrefs |
subset | A oboInOwl:inSubset | cohort tag |
All rows must be padded to the same column count (trailing tabs for empty cells), or ROBOT will reject the template.
# 3a. Compile each template into OWL — fails on syntax errors
robot template \
--template mappings/metpo_proposal_classes_robot.tsv \
--prefix "METPO: http://purl.obolibrary.org/obo/METPO_" \
--prefix "biolink: https://w3id.org/biolink/vocab/" \
--output /tmp/metpo_classes.owl
robot template \
--template mappings/metpo_proposal_properties_robot.tsv \
--prefix "METPO: http://purl.obolibrary.org/obo/METPO_" \
--prefix "biolink: https://w3id.org/biolink/vocab/" \
--output /tmp/metpo_props.owl
# 3b. Merge classes + properties into a single proposal artifact
robot merge \
--input /tmp/metpo_classes.owl \
--input /tmp/metpo_props.owl \
--output /tmp/metpo_proposal_merged.owl
# 3c. ELK reason — fails on inconsistencies / unsatisfiable classes
robot reason \
--reasoner ELK \
--input /tmp/metpo_proposal_merged.owl \
--axiom-generators "SubClass EquivalentClass" \
--output /tmp/metpo_proposal_reasoned.owl
Pass criteria:
UNSAT / inconsistent warnings on stderr.Common failures and fixes:
| Symptom | Cause | Fix |
|---|---|---|
Number of columns ... does not match | directive row shorter than data rows | pad header row 2 with trailing tabs |
Could not parse: <directive> | typo in directive (e.g. A IAO 0000115) | use space between directive code and CURIE: A IAO:0000115 |
UNSAT class: <CURIE> | conflicting parent/disjoint axioms | review parent chain; check if a sibling class is disjoint via PATO/OBI |
Inconsistent ontology | conflicting domain/range vs. parent property | tighten domain/range or relax parent |
New EquivalentClasses axiom in reasoned output | two children mapped to same parent + same definition pattern collapse | review definition uniqueness |
The submittable artifacts are:
mappings/metpo_proposal_classes_robot.tsvmappings/metpo_proposal_properties_robot.tsv/tmp/metpo_proposal_reasoned.owl (for reviewers who prefer OWL)File a PR or issue at berkeleybop/metpo with the TSVs attached. Reference the subset tag (e.g. metpo_proposal_2026_04) so reviewers can filter.
Aristotelian convention (genus + differentia):
<term>: <existing parent class> with <distinguishing feature>.
Examples in current proposal:
circular colony = "Colony shape with a regular round outline."fried-egg-shaped colony = "Colony shape with a raised opaque centre and translucent peripheral zone, resembling a fried egg."catalase positive = "Catalase activity phenotype in which the catalase test yields a positive result, characterised by visible bubbling on H2O2."Avoid:
Flagellar arrangement in which ...).Every term needs IAO:0000119. Acceptable forms:
| Source | CURIE pattern | Example |
|---|---|---|
| BacDive strain entry | BacDive:strain/<id> | BacDive:strain/13245 |
| Bergey's Manual | ISBN:<isbn> | ISBN:9780470654958 |
| Reused PATO/GO definition | the source CURIE itself | PATO:0000052 |
| Peer-reviewed paper | PMID:<id> or DOI:<doi> | PMID:31123456 |
| Working draft (placeholder) | TODO:add_citation | only acceptable in pre-submission drafts |
A proposal with only TODO:add_citation placeholders should NOT be submitted upstream.
Prefer the most specific existing METPO parent. Audit chain:
data/transformed/ontologies/metpo_nodes.tsv for sibling concepts.METPO:1000332 = pH tolerance), use it as parent.METPO:1000000 for genuinely top-level new categories.Mass SC METPO:1000000 is a code smell — flag it during review.
When you mint a new ID, place it in the range that already groups its kind. METPO splits into two families by leading digit:
| Range | What lives there | Example |
|---|---|---|
METPO:1000xxx | Classes (organism, environment, phenotype, enzyme, growth medium, …) | METPO:1000525 microbe, METPO:1000526 chemical entity, METPO:1000527 enzyme, METPO:1004005 growth medium |
METPO:1004xxx | Growth-medium classes | METPO:1004005 growth medium and its children |
METPO:1005xxx | Test-result / assay classes | METPO:1005010 indole test, METPO:1005011 indole test positive |
METPO:1007xxx | KG-Microbe proposal classes (pre-mint cohort) | All proposed classes in this PR cohort |
METPO:2000001-2000020 | Object properties — chemical interaction, positive | METPO:2000002 assimilates, METPO:2000006 uses as carbon source |
METPO:2000021-2000056 | Object properties — chemical interaction, negative (paired with the matching positive ~25 IDs lower; gaps in 2000040-2000056 also hold positive extensions) | METPO:2000027 does not assimilate, METPO:2000031 does not use as carbon source |
METPO:2000057, 2000064-2000070 | Object-property gaps in the chemical-interaction range — use these for new pairs | METPO:2000064 tolerates / METPO:2000065 does not tolerate |
METPO:2000101-2000103 | High-level capability/phenotype predicates | METPO:2000102 has phenotype, METPO:2000103 capable of |
METPO:2000202, 2000222 | Production predicates | METPO:2000202 produces / METPO:2000222 does not produce |
METPO:2000302/2000303 | Enzyme-activity predicates | shows activity of / does not show activity of |
METPO:2000517/2000518 | Growth-medium predicates | grows in / does not grow in |
METPO:2000601-2000606 | Process predicates | denitrifies, ammonifies, oxidizes in darkness, … |
METPO:2000701-2000709, 2000711-2000716, 2000721+ | Datatype properties — observational values | METPO:2000702 has minimum temperature value, METPO:2000715 has GC percentage value |
METPO:2000717-2000720 | Datatype-property gaps in the value-property family — use these for new value/optimum properties | METPO:2000717 has growth temperature optimum value |
Rules of thumb:
grep -nE "metpo/2000[0-9]{3}\"" data/raw/metpo.owl | grep -E "DatatypeProperty|ObjectProperty") and pick the next free slot in the conceptual range. The current gaps as of metpo_proposal_2026_04:
2000057, 2000064-2000070. Adjacent positive/negative pairs are preferred over the legacy "+25 offset" pattern when the offset would push you outside the conceptual range.2000710, 2000717-2000720.1007xxx is reserved for KG-Microbe proposals; pick the next unused 1007NNN slot in the relevant subrange.extract_metpo_proposals.py, note WHY this ID was picked ("placed in the 2000064-2000070 gap of the chemical-interaction object-property family because …"). Keeps future curators from re-shuffling.The metatraits transform's _build_metpo_lookups (kg_microbe/transform_utils/metatraits/metatraits.py:919, helper _get_negative_predicate at metatraits.py:2103) auto-pairs METPO predicates so a downstream call like
self._get_negative_predicate("METPO:2000064") # tolerates
# → "METPO:2000065" # does not tolerate
resolves the partner without any hardcoded table. The pairing rule:
rdfs:label MUST start with does not (lowercased). The loader uses this prefix to flag the entry as the negative half.oboInOwl:hasRelatedSynonym (or label) so they end up under the same metpo_pattern_to_predicate key.Worked example — METPO:2000002 / 2000027:
| METPO:2000002 (positive) | METPO:2000027 (negative) | |
|---|---|---|
| label | assimilates | does not assimilate |
| synonym | assimilation | assimilation |
Builds key assimilation | positive=METPO:2000002 | negative=METPO:2000027 |
Result: metpo_pattern_to_predicate["assimilation"] = {positive: METPO:2000002, negative: METPO:2000027}. _get_negative_predicate(METPO:2000002) iterates the dict, finds the entry where positive==METPO:2000002, and returns its negative.
Counter-example (broken pairing) — METPO:2000517/2000518 in the current upstream release:
| METPO:2000517 | METPO:2000518 | |
|---|---|---|
| label | grows in | does not grow in |
| synonyms | (none) | (none) |
| Built keys | positive["grows in"]=2000517 | negative["does not grow in"]=2000518 |
No shared key → not paired → _get_negative_predicate("METPO:2000517") returns None → false-majority grows in observations are silently dropped. Fix: add a shared related synonym to both upstream (e.g. growth medium relation or growth in medium).
When proposing a new paired predicate, always:
does not <stem> as the negative label.oboInOwl:hasRelatedSynonym (a noun-form of the relation works well: tolerance, assimilation, production).is susceptible to, is sensitive to) — these become extra entries in metpo_pattern_to_predicate keyed on those synonyms but, because they're only on the negative member, they don't interfere with the pairing.The proposal occasionally has a choice: encode an organism-chemical relationship as a predicate-driven edge (organism --P--> chemical) or as a class-subdivision phenotype (organism --has phenotype--> "X-susceptible" class). Default to the predicate, not the class.
| Modeling choice | Use when |
|---|---|
Predicate-driven (mint or reuse a paired predicate; emit org --P--> chem/medium/enzyme/process) | The relationship is parametric over a chemical/medium/enzyme axis. New axis values shouldn't require new ontology mints. Examples: tolerates(org, chem), grows in(org, medium), shows activity of(org, enzyme). |
Class-subdivision (mint a phenotype class per outcome and use biolink:has_phenotype / METPO:2000102) | The "outcome" is qualitative and not a function of a chemical/medium/enzyme. Examples: cell shape (rod-shaped, coccus-shaped), colony morphology (circular, irregular, fried-egg-shaped), Gram stain (positive/negative). |
Smell: a class hierarchy whose name encodes a chemical or medium (bile acid susceptible, growth on MacConkey agar, catalase positive) is a candidate for collapse into a predicate-driven pattern. The METPO proposal in metpo_proposal_2026_04 removed three such hierarchies (growth on {MacConkey,blood,EMB} agar and bile acid response/susceptible) in favour of the predicate-driven equivalents (METPO:2000517 grows in and METPO:2000064/2000065 tolerates / does not tolerate).
Test-outcome classes are a special case — they encode a bench observation (catalase test positive) that is downstream of the underlying enzyme activity. Keep the test-outcome class AND assert the underlying predicate edge in parallel; the class records "the assay was performed and yielded outcome X", the predicate records "the organism has activity Y".
All proposal rows must be tagged with a cohort identifier so curators can filter:
subset A oboInOwl:inSubset
metpo_proposal_2026_04
Use a date-stamped string (metpo_proposal_<YYYY>_<MM>). On the next proposal cohort, mint a new value (don't reuse).
When this skill is invoked, run through:
scripts/extract_metpo_proposals.py exits cleanpytest tests/test_extract_metpo_proposals.py tests/test_metatraits.py passes*_robot.tsv files have two header rows, consistent column countsdefinition_source (no TODO:add_citation if submitting)subset cohort tagrobot template succeeds for both class + property TSVsrobot merge produces a single OWLrobot reason --reasoner ELK exits clean with no UNSAT classesSC METPO:1000000 (>3 rows) without curator reviewdoes not <stem> AND a shared oboInOwl:hasRelatedSynonym with its positive partner — verify by simulating _build_metpo_lookups against the proposal OWLMETPO_LABEL_CORRECTIONS cites a berkeleybop/metpo issue and the validate_label_corrections() freshness check passes (entries become stale once upstream fixes them — re-check before re-shipping)metpo-ontology skill — for using existing METPO terms in transforms (the inverse direction)scripts/extract_metpo_proposals.py — proposal generation source