| name | scvi-tools |
| description | Deep generative models for single-cell omics. Use when you need probabilistic batch correction (scVI), transfer learning, differential expression with uncertainty, or multi-modal integration (TOTALVI, MultiVI). Best for advanced modeling, batch effects, multimodal data. For standard analysis pipelines use scanpy. |
| license | BSD-3-Clause license |
| metadata | {"skill-author":"K-Dense Inc."} |
| verified | false |
| lastVerifiedAt | "2026-02-19T05:29:09.098Z" |
| source | builtin |
| trust_score | 100 |
| provenance_sha | 1bdd2cc0fd4df8f9 |
scvi-tools
Overview
scvi-tools is a comprehensive Python framework for probabilistic models in single-cell genomics. Built on PyTorch and PyTorch Lightning, it provides deep generative models using variational inference for analyzing diverse single-cell data modalities.
When to Use This Skill
Use this skill when:
- Analyzing single-cell RNA-seq data (dimensionality reduction, batch correction, integration)
- Working with single-cell ATAC-seq or chromatin accessibility data
- Integrating multimodal data (CITE-seq, multiome, paired/unpaired datasets)
- Analyzing spatial transcriptomics data (deconvolution, spatial mapping)
- Performing differential expression analysis on single-cell data
- Conducting cell type annotation or transfer learning tasks
- Working with specialized single-cell modalities (methylation, cytometry, RNA velocity)
- Building custom probabilistic models for single-cell analysis
Core Capabilities
scvi-tools provides models organized by data modality:
1. Single-Cell RNA-seq Analysis
Core models for expression analysis, batch correction, and integration. See references/models-scrna-seq.md for:
- scVI: Unsupervised dimensionality reduction and batch correction
- scANVI: Semi-supervised cell type annotation and integration
- AUTOZI: Zero-inflation detection and modeling
- VeloVI: RNA velocity analysis
- contrastiveVI: Perturbation effect isolation
2. Chromatin Accessibility (ATAC-seq)
Models for analyzing single-cell chromatin data. See references/models-atac-seq.md for:
- PeakVI: Peak-based ATAC-seq analysis and integration
- PoissonVI: Quantitative fragment count modeling
- scBasset: Deep learning approach with motif analysis
3. Multimodal & Multi-omics Integration
Joint analysis of multiple data types. See references/models-multimodal.md for:
- totalVI: CITE-seq protein and RNA joint modeling
- MultiVI: Paired and unpaired multi-omic integration
- MrVI: Multi-resolution cross-sample analysis
4. Spatial Transcriptomics
Spatially-resolved transcriptomics analysis. See references/models-spatial.md for:
