Use this skill for any protein 3D structure analysis using MICAN: alignment, TM-score, RMSD, structural similarity, superposition, batch comparison, residue correspondence, conformational change (apo/holo), internal symmetry detection, rotational symmetry (Cn), domain detection, sub-optimal alignments, cyclic permutation, tandem repeat. Trigger on phrases like "compare PDB files", "align proteins", "calculate TM-score", "run MICAN", "structural similarity", "does this protein have symmetry", "analyze conformational change", "show alternative alignments", or whenever PDB file paths are provided. Symmetry analysis, conformational change quantification, and domain detection are all within scope — trigger even when the task goes beyond simple alignment.
2026-04-10
