// Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.
Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence.
Query or inspect the FDA Orange Book - FDA-Approved Drug Products Listing resource for drug-centric tasks with emphasis on drug knowledgebase Use whenever Codex needs the calling pattern, downloadable entrypoint, or example query flow from this skill example script.
Query the RepurposeDrugs single-agent drug repurposing database. Use whenever the user asks about drug-disease repurposing associations, clinical trial phases for repurposed drugs, or wants to look up any entity (drug name, disease name, NCT ID) in RepurposeDrugs.
Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.
Query canonical TarKG drug-target triplets. Use when the user asks about drug-target interactions, relation labels, disease/pathway context, or quick lookups for drugs/targets in TarKG.
Query the MecDDI mechanism-based drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI mechanisms (PK/PD), enzyme or transporter-mediated interactions, or wants to look up interacting drug pairs by drug name or MecDDI drug ID. Trigger on keywords like DDI, drug interaction, MecDDI, mechanism-based interaction, pharmacokinetic interaction, pharmacodynamic interaction, or any query involving two drugs that may interact.
| name | DrugComb |
| description | Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line. |
Search DrugComb summary records by any entity. Auto-detects type by pattern:
| Input Pattern | Detected As | Match Logic |
|---|---|---|
5-FU / imatinib | drug name | case-insensitive substring on drug_row OR drug_col |
A549 / MCF-7 | cell line | case-insensitive substring on cell_line_name |
12345 (pure digits) | block_id | exact on block_id |
CID:2244 | PubChem CID | exact on drug_row_cid OR drug_col_cid |
| Function | Input | Returns |
|---|---|---|
load_drugcomb(path) | CSV path | list[dict] |
columns(data) | loaded data | column name list |
search(data, entity) | single entity string | list[dict] |
search_batch(data, entities) | list of entity strings | dict[str, list[dict]] |
summarize(hits, entity) | hit list + label | compact LLM-readable text |
to_json(hits) | hit list | list[dict] |
See if __name__ == "__main__" block in example.py for runnable examples covering: drug name search, cell-line search, batch search, and JSON output.
drug_row, drug_col, cell_line_name, synergy_zip, synergy_blissresources_metadata/drug_combination/DrugComb/drugcomb.csvZagidullin B, Aldahdooh J, Zheng S, et al. DrugComb: an integrative cancer drug combination data portal. Nucleic Acids Res. 2019;47(W1):W43–W51. doi:10.1093/nar/gkz337