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Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.
Codex 또는 Claude로 설치 이 Prompt를 복사해 Codex, Claude 또는 다른 어시스턴트에 붙여 넣으면 Skill 페이지를 검토하고 설치를 진행할 수 있습니다.
SOC 직업 분류 기준
Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.
Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence.
Query or inspect the FDA Orange Book - FDA-Approved Drug Products Listing resource for drug-centric tasks with emphasis on drug knowledgebase Use whenever Codex needs the calling pattern, downloadable entrypoint, or example query flow from this skill example script.
Query the RepurposeDrugs single-agent drug repurposing database. Use whenever the user asks about drug-disease repurposing associations, clinical trial phases for repurposed drugs, or wants to look up any entity (drug name, disease name, NCT ID) in RepurposeDrugs.
Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.
Query canonical TarKG drug-target triplets. Use when the user asks about drug-target interactions, relation labels, disease/pathway context, or quick lookups for drugs/targets in TarKG.
| name | 48_LTKB |
| description | Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets. |
Search FDA LTKB records (DILIrank 2.0 + DILIst) by any entity. Auto-detects type by pattern:
| Input Pattern | Detected As | Searched In |
|---|---|---|
LT00040 | LTKB ID | DILIrank only |
2 (digits) | DILIst ID | DILIst only |
| anything else | drug name | both datasets (substring) |
DILIrank 2.0 — 1,036 FDA-approved drugs ranked by DILI concern:
| vDILI-Concern | Meaning |
|---|---|
| vMOST-DILI-concern | Strong evidence of causing DILI |
| vLess-DILI-concern | Some evidence of causing DILI |
| vNo-DILI-concern | No credible evidence |
| vAmbiguous-DILI-concern | Conflicting/insufficient evidence |
Columns: LTKBID, CompoundName, SeverityClass, LabelSection, vDILI-Concern, Comment
DILIst — 1,279 drugs classified by DILI severity:
| Classification | Meaning |
|---|---|
| 1 | DILI-positive |
| 0 | DILI-negative |
Columns: DILIST_ID, CompoundName, DILIst Classification, Routs of Administration
| Function | Input | Returns |
|---|---|---|
load_all(rank_path, list_path) | Excel paths | {"dilirank": [...], "dilist": [...]} |
search(data, entity) | data dict + entity string | {"entity", "type", "dilirank": [], "dilist": []} |
search_batch(data, entities) | data dict + list of strings | {entity: search_result} |
summarize(result, entity) | search result + label | compact text |
to_json(result) | search result | JSON string |
See if __name__ == "__main__" block in 48_LTKB.py for runnable examples covering: drug name, LTKB ID, DILIst ID, batch search, and JSON output.
Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset FDA.xlsx, DILIst Supplementary Table.xlsxDATA_DIR variable in 48_LTKB.py