tooluniverse-adverse-outcome-pathway

name

tooluniverse-adverse-outcome-pathway

description

Map environmental and industrial chemicals to adverse outcome pathways (AOPs) — molecular initiating event to organ-level toxicity. Uses AOPWiki, GHS classification, IARC carcinogen status, and LD50 data. Use for environmental/industrial chemical risk assessment, regulatory-grade hazard characterization, and AOP stressor mapping. Distinct from drug-safety analysis (use tooluniverse-pharmacovigilance for drugs).

Adverse Outcome Pathway & Regulatory Risk Assessment

Distinct from drug safety (see tooluniverse-toxicology): this skill targets environmental and industrial chemicals where the focus is AOP stressor mapping, GHS classification, LD50 hazard quantification, and IARC carcinogen status — not FAERS signals or FDA drug labels.

When to Use

Apply when researcher asks about:

• "What AOPs are associated with [pesticide/solvent/industrial chemical]?"
• "What is the GHS hazard classification for [compound]?"
• "What is the LD50 for [compound]?"
• "Is [compound] a carcinogen (IARC classification)?"
• "Which genes does [chemical] interact with (CTD)?"
• "Regulatory risk assessment for [environmental chemical]"
• "What diseases are associated with [chemical] exposure?"

Do NOT use for FDA-approved drugs with FAERS data — use tooluniverse-toxicology instead.

Key Tools

Tool	Purpose	Key Params
AOPWiki_list_aops	Discover AOPs by keyword	keyword (organ, effect, or target name)
AOPWiki_get_aop	Full AOP details: MIE, key events, stressors	aop_id (int)