tooluniverse-drug-synergy

name

tooluniverse-drug-synergy

description

Drug-combination synergy analysis — quantify whether two drugs together are synergistic, additive, or antagonistic using the standard reference models (Bliss independence, HSA / highest single agent, Loewe additivity, ZIP, and the Chou-Talalay Combination Index). Use when you have measured single-drug and combination effects (inhibition/viability) and need a synergy score. Explains which model to use, what data each one needs, and how to read the score. NOT for looking up pre-computed synergy in a database (use the SYNERGxDB tool / cell-line-profiling skill).

Drug-Combination Synergy Analysis

Decide whether a two-drug combination does more than expected (synergy), exactly as expected (additivity), or less (antagonism) — and pick the right reference model for the data you have.

"Synergy" only means something relative to a null model of additivity, and the models define additivity differently — so the first decision is which model, driven by what data you measured.

Step 0 — Pick the model by the data you have

You measured…	Use model	Tool	Input
Single effects of A, B, and A+B at one dose pair	Bliss	DrugSynergy_calculate_bliss	effect_a, effect_b, effect_combination (each a fraction 0–1)
Effects of A, B, A+B across several dose points	HSA	DrugSynergy_calculate_hsa	effects_a, effects_b, effects_combo (arrays)