gdkd-query

name	GDKD-query
description	Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.

GDKD Query Skill

Search canonical GDKD rows by drug or gene entity. Auto-detects input type by pattern:

Input Pattern	Detected As	Match Logic
ABL1, EGFR	Gene symbol	substring on gene
imatinib, erlotinib	Drug name	substring on drug
anything else	Free text	substring on drug OR gene

API

Function	Input	Returns
load_gdkd(path)	CSV path	list[dict]
search(rows, entity)	single entity string	list[dict]
search_batch(rows, entities)	list of entity strings	dict[str, list[dict]]
summarize(hits, entity)	rows + label	compact text
to_json(hits)	rows	list[dict]

Usage

See if __name__ == "__main__" block in example.py for runnable examples.

Data

• Source: GDKD normalized full-package output
• Paper: Dienstmann et al., Cancer Discovery 2015;5(2):118-123
• Format: CSV
• Columns: drug, gene, score, source
• Path: resources_metadata/dti/GDKD/gdkd.csv (default DATA_PATH in example.py)