菜单
Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs.
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基于 SOC 职业分类
Load BioMaster as one integrated skill-driven bioinformatics assistant.
BioMaster conversational bioinformatics assistant; starts workflows only after execution intent or empty activation.
Automated and marker-guided single-cell cell type annotation using CellTypist, marker review, reference transfer, and confidence-aware label curation.
Ligand-receptor communication inference in single-cell or spatial data with sender-receiver summaries and cautious interpretation.
Workflow for paired or integrated single-cell RNA and ATAC analysis with multimodal latent spaces and regulatory interpretation.
Workflow for spatial transcriptomics preprocessing, domain detection, deconvolution, neighborhood analysis, and publication-ready spatial maps.
| name | bioskills-combinatorial-screens |
| description | Analyze combinatorial CRISPR screens (Big Papi paired-Cas9 or in4mer/Inzolia Cas12a multiplex) to score synthetic-lethal and synthetic-rescue genetic interactions between gene pairs. |
| domain | single-cell |
| primary_tool | MAGeCK |
| methods | ["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring"] |
| macro_tags | ["combinatorial-crispr","genetic-interaction","synthetic-lethal","paralog-buffering","screen-analysis"] |
| micro_tags | ["mageck-mle","cas12a-multiplex","big-papi","in4mer","inzolia","gi-scoring","library-design","architecture-selection","singleton-controls","cas12a","qc","library-skew","gini","singleton-verification","coverage","interaction-terms","design-matrix","cas9","cassette-aggregation","lfc","synthetic-lethal","synthetic-rescue","additive-null","zscore","failure-diagnosis","validation","saturation","cross-modality","quality-control"] |
| source | bioskills-combinatorial-screens |
| status | active |
| enabled | true |
