| name | proteomics-benchmarks |
| version | 0.1.0 |
| description | Reference benchmark datasets for proteomics DEA optimization. Contains ground-truth metadata, expected fold-changes, and best-known method configurations. Used by the evaluator to score candidate workflows against known references.
|
Proteomics Benchmarks
Reference datasets with ground truth for evaluating differential expression
analysis workflows.
PXD001819
- Description: UPS1 spike-in, 27 runs, 9 conditions, LFQ, Orbitrap Velos
- Ground-truth proteins: ups1_48_proteins.txt
- Expected log2FC:
| Contrast | log2FC |
|---|
| A_vs_B | 2.0 |
| A_vs_C | 4.32 |
| A_vs_D | 7.64 |
| B_vs_C | 2.32 |
| B_vs_D | 5.64 |
| C_vs_D | 3.32 |
- Best-known configuration:
- Method: deqms
- FDR method: ihw
- Imputation: none
- Metrics: AUC 0.996, TP 47, FP 1