菜单
Causal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists.
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基于 SOC 职业分类
Use this skill for genetics, genome source, variant, gene, phenotype, disease, screen, pharmacogenomics, and Genomi install/setup maintenance questions.
Build and inspect ClinVar exact-match evidence and candidate inventories. Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.
Activate this skill for "/genomi decode", "decode my genome", "decode my DNA", "show me the dashboard", "the Genomi dashboard", "one-shot rundown", or any all-at-once request that asks Genomi to compose every capability's findings into a single artifact. This is the whole-genome dashboard kicker — it sweeps every relevant Genomi capability in one shot, not a per-target lookup. Composes evidence from every relevant Genomi capability into a single self-contained Genomi Dashboard.html and returns localhost serve metadata. Active genome required.
Answer drug-response, medication, PharmGKB-style, PGxDB, ATC, DrugBank, gene-drug, and variant-drug questions using public PGx evidence plus local sample genotype support when an Active Genome Index is selected.
Plan rare disease, hereditary disease, cancer risk, carrier-relevance, and observed-condition source investigation from public targets or selected active genome evidence.
Answer specific rsID, allele, gene, region, genotype, and absence/callability questions using explicit session context or public evidence.
| name | drug-targets |
| description | Causal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists. |
| tools | ["phenotype.retrieve_disease_drug_targets","phenotype.compare_drug_target_evidence","research.list_sources","research.record","research.query","research.search"] |
| mutating | true |
Use this skill for disease-scoped clinical drug-target retrieval, direct drug-target records, PharmaProjects-style target context, ChEMBL mechanism genes, DrugBank target context, or candidate-gene review for a drug, drug class, or mechanism.
prior_fit before reading a panel as task-relevant and audit
decision_evidence before answering.phenotype.retrieve_disease_drug_targets retrieves Open Targets clinical
drug candidate target genes for a supplied disease anchor.phenotype.compare_drug_target_evidence compares candidate genes against direct
drug-side context: drug, drug class, or mechanism.research.list_sources to choose direct target
sources, review them, and store narrow findings with research.record.Example:
phenotype.retrieve_disease_drug_targets with {"disease":"asthma","genes":["ADRB2","IL13"]}phenotype.compare_drug_target_evidence with {"drug_class":"beta agonist","phenotype":"asthma","genes":["ADRB2","IL13"],"source_records":[{"genes":["ADRB2"],"drug_class":"beta agonist","verified_fields":{"genes":["ADRB2"],"drug_class":"beta agonist"},"support_spans":[{"field":"genes","text":"source-backed ADRB2 text"}]}]}Prefer source records with:
genes: candidate target genes named by the source.drug, drug_class, indication, or mechanism.source_title, source_url, and source_type.finding or text: short source-backed finding.verified_fields and support_spans showing where the source supports the
gene and drug-target or mechanism context.Use a direct gene-symbol answer only when reviewed evidence supports the drug-target or mechanism relationship requested by the question. Otherwise state the source gap and summarize the strongest reviewed evidence without presenting it as the final target.
A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.
Compare candidate genes using direct drug-target or mechanism evidence only.
Use when: Returns direct drug-target, target-mechanism, ChEMBL, DrugBank, or PharmaProjects evidence for candidate genes.
Why necessary: Drug-target questions require direct target/mechanism evidence, which is distinct from disease association evidence.
Result semantics: Returns source-local drug-target evidence only; association-only evidence cannot create direct target support.
Retrieve disease-scoped clinical drug-target genes from Open Targets drug candidate records.
Use when: Returns Open Targets clinical drug candidate target genes for a supplied disease anchor, with optional gene_membership projection for supplied candidate genes.
Why necessary: Clinical drug-target records answer therapeutic-target membership without implying causal genetics or treatment efficacy.
Result semantics: Returns disease-scoped clinical drug-target records and source-local ordering; the host agent decides how they apply. mode='gene_membership' projects the same source records into per-gene membership booleans and highest observed phase for supplied genes. Does not ingest agent-supplied evidence and does not infer treatment efficacy or final causal-gene answers.