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Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
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基于 SOC 职业分类
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| name | genome-compare |
| description | Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture |
| version | 0.1.0 |
| author | Manuel Corpas |
| license | MIT |
| tags | ["genome-comparison","IBS","ancestry","PGP","admixture"] |
| metadata | {"genetind":{"requires":{"bins":["python3"],"env":[],"config":[]},"always":false,"emoji":"🧬","homepage":"https://github.com/ClawBio/ClawBio","os":["macos","linux"],"install":[],"trigger_keywords":["genome comparison","IBS","identity by state","George Church","Corpasome","pairwise"]}} |
You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.
| Format | Extension | Required Fields | Example |
|---|---|---|---|
| 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | data/manuel_corpas_23andme.txt.gz |
George Church (hu43860C) — the first participant in the Personal Genome Project. Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in data/george_church_23andme.txt.gz.
.txt.gz)report.md with summary, IBS analysis, ancestry composition, and methods# Demo: Manuel Corpas vs George Church
python skills/genome-compare/genome_compare.py --demo --output results/
# Your own data vs George Church
python skills/genome-compare/genome_compare.py --input your_23andme.txt --output results/
# Via ClawBio runner
python clawbio.py run compare --demo
python clawbio.py run compare --input <file> --output <dir>
python clawbio.py run compare --demo
Expected output: A report comparing Manuel Corpas (PGP-UK uk6D0CFA) vs George Church (PGP-1 hu43860C). IBS score ~0.74 (consistent with two unrelated Europeans). Ancestry estimates for both individuals. Four figures generated.
output_directory/
├── report.md # Full comparison report
├── result.json # Machine-readable IBS and ancestry data
├── figures/
│ ├── chromosome_ibs.png # Per-chromosome IBS bar chart
│ ├── ancestry_pie.png # Ancestry composition pie chart
│ ├── ibs_context.png # IBS score on relationship spectrum gauge
│ └── ancestry_comparison.png # Side-by-side ancestry comparison
└── reproducibility/
└── commands.sh # Exact command to reproduce
Required:
numpy >= 1.24matplotlib >= 3.7Trigger conditions — the orchestrator routes here when:
Chaining partners:
claw-ancestry-pca: More detailed ancestry analysis with SGDP reference panelprofile-report: Genome comparison results feed into the unified genomic profile