菜单
Query the nSIDES drug side effect databases (OnSIDES, OffSIDES, KidSIDES). Use whenever the user asks about drug adverse reactions, side effects, off-label safety signals, or pediatric drug safety for a given drug name.
用 Codex 或 Claude 帮你安装 复制这段 Prompt，粘贴到 Codex、Claude 或其他助手里，让它检查 Skill 页面并帮你完成安装。
基于 SOC 职业分类
| name | nsides-query |
| description | Query the nSIDES drug side effect databases (OnSIDES, OffSIDES, KidSIDES). Use whenever the user asks about drug adverse reactions, side effects, off-label safety signals, or pediatric drug safety for a given drug name. |
Search drug adverse reactions across three complementary nSIDES sources by drug name.
| Source | Content | Method | Scale |
|---|---|---|---|
| OnSIDES v3.1.0 | Label-extracted ADEs (US/EU/UK/JP) | PubMedBERT NLP on product labels | 1,955 ingredients, 5.5M drug-ADE pairs |
| OffSIDES | Off-label side effects | Propensity-score matching on FAERS | 3,300+ drugs |
| KidSIDES | Pediatric safety signals by developmental phase | Disproportionality analysis on FAERS | Age-stratified ADE signals |
| Input | Routing |
|---|---|
| any free text | substring match on drug / ingredient name across all three sources |
No ID-based routing — all queries are natural-language drug names.
| Function | Input | Returns |
|---|---|---|
search(entity, limit) | drug name string | dict with keys: entity, onsides, offsides, kidsides |
search_batch(entities, limit) | list of drug names | list[dict] |
search_onsides(drug_name, limit) | drug name | list[dict] — ingredient, effect, meddra_id, source, label_count |
search_offsides(drug_name, limit) | drug name | list[dict] — drug, condition, PRR, A/B/C/D |
search_kidsides(drug_name, limit) | drug name | list[dict] — drug, event, nichd_phase, gam_score, ror |
summarize(result) | single search() output | compact text |
to_json(result) | single search() output | JSON string |
ingredient — RxNorm ingredient nameeffect — MedDRA adverse effect termmeddra_id — MedDRA concept IDsource — label origin country (US / EU / UK / JP)label_count — number of labels reporting this ADEdrug — RxNorm drug namecondition — MedDRA side effect namePRR — proportional reporting ratio (>1 = signal)A/B/C/D — 2×2 contingency countsmean_reporting_frequency — proportion of drug reports with this effectdrug — drug concept nameevent — adverse event namenichd_phase — NICHD developmental phase (e.g. "Neonatal", "Infancy", "Adolescence")gam_score — GAM model scoreror / ror_lower / ror_upper — reporting odds ratio with 95% CISee if __name__ == "__main__" block in 15_nSIDES.py for runnable examples:
single-drug query, batch query, text summary, and JSON output.
| File | Location | Size |
|---|---|---|
onsides.db | DATA_DIR/onsides.db | SQLite, from OnSIDES v3.1.0 release |
OFFSIDES.csv.gz | DATA_DIR/OFFSIDES.csv.gz | gzipped CSV |
ade_nichd.csv.gz | DATA_DIR/ade_nichd.csv.gz | gzipped CSV (172 MB) |
drug.csv.gz | DATA_DIR/drug.csv.gz | KidSIDES drug dictionary |
event.csv.gz | DATA_DIR/event.csv.gz | KidSIDES event dictionary |
dictionary.csv.gz | DATA_DIR/dictionary.csv.gz | NICHD phase dictionary |
DATA_DIR default: resources_metadata/adr/nSIDES
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Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence.
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