| name | NCI-DTP-MolTarget |
| description | Query the NCI-60 Molecular Target (Protein) database from the Developmental Therapeutics Program. Use when the user asks about protein expression of drug targets across the NCI-60 cancer cell line panel, or wants to look up a gene, cell line, or cancer panel in the NCI DTP molecular target dataset.
|
NCI DTP Molecular Target Query Skill
Search NCI-60 protein-level molecular target data by any entity. Auto-detects type:
| Input Pattern | Detected As | Match Logic |
|---|
EGFR, TP53 | gene / protein | exact on GENE or substring on ENTITY_MEASURED, TITLE |
MCF7, NCI-H460 | cell line | substring on cellname |
Breast, Leukemia | cancer panel | substring on pname |
12345 (pure digits) | MOLTID | exact on MOLTID (NCI pattern #) |
Drug-Relevance Guide
Only protein expression data is downloaded — proteins are the direct molecular
targets of drugs (kinase inhibitors → kinase expression, antibodies → receptor levels).
| Dataset | Download? | Reason |
|---|
| WEB_DATA_PROTEIN.ZIP | YES | Drug targets: protein expression across NCI-60 |
| WEB_DATA_ALL_MT.ZIP | Optional | Superset incl. enzyme activity (also drug-relevant) |
| WEB_DATA_DNA.ZIP | No | Genomic characterisation, not drug targets |
| WEB_DATA_SEQUENOM_METHYLATION.ZIP | No | Epigenetic; indirect |
| WEB_DATA_*_MIR.ZIP | No | microRNA regulation; indirect |
| WEB_DATA_METABOLON*.ZIP | No | Metabolomics; downstream, indirect |
| Microarray / SNP / CopyNum / Karyotype | No | Cell-line genomic profiling; indirect |
API
| Function | Input | Returns |
|---|
load_data(path) | file or directory path | list[dict] |
search(data, entity) | data + single entity string | list[dict] |
search_batch(data, entities) | data + list of entity strings | dict[str, list[dict]] |
summarize(hits, entity) | hit list + label | compact LLM-readable text |
to_json(hits) | hit list | list[dict] (JSON-serialisable) |
query(data, entities, top_n) | data + str or list | text block |
Record Fields
Each record contains:
| Field | Description |
|---|
MOLTID | NCI pattern number (molecular target ID) |
GENE | Gene symbol |
TITLE | Gene / protein full name |
MOLTNBR | NCI experiment ID |
PANELNBR / CELLNBR | Internal panel / cell identifiers |
pname | Cancer panel name (e.g., Breast, Leukemia) |
cellname | Cell line name (e.g., MCF7, A549/ATCC) |
ENTITY_MEASURED | What was measured (e.g., protein name) |
GeneID | NCBI Gene ID |
UNITS | Measurement units |
METHOD | Assay method |
VALUE | Numeric measurement value |
TEXT | Additional notes |
Usage
See if __name__ == "__main__" block in 16_NCI_DTP_MolTarget.py for runnable
examples covering: single gene query, cell line profile, batch multi-target
search, cancer panel query, and JSON output.
Quick Examples
from importlib.machinery import SourceFileLoader
mt = SourceFileLoader("mt", "16_NCI_DTP_MolTarget.py").load_module()
data = mt.load_data()
print(mt.query(data, "EGFR"))
print(mt.query(data, ["TP53", "BRAF", "HER2"]))
print(mt.query(data, "MCF7"))
import json
hits = mt.search(data, "EGFR")
print(json.dumps(mt.to_json(hits[:5]), indent=2))
Data Source & Download
Download Commands
