菜单
Annotate variants with functional effects using SnpEff or Ensembl VEP, adding gene impact, population frequencies, and clinical significance.
用 Codex 或 Claude 帮你安装 复制这段 Prompt，粘贴到 Codex、Claude 或其他助手里，让它检查 Skill 页面并帮你完成安装。
基于 SOC 职业分类
Decision-grade enzyme/protein mutation design for thermostability with bioactivity-preserving constraints enforced by default, plus structure-aware and consensus-ranking workflows.
Create or update repository skills that conform to local templates, provider metadata requirements, registry rules, and validation workflows.
Assess data quality by reporting missing values, outliers, sample size, and variance structure for each variable in a table.
Estimate model parameters using Bayesian inference (MCMC via Stan or PyMC), returning posterior distributions and credible intervals.
Cluster samples or features using k-means or hierarchical clustering, evaluate cluster quality with silhouette scores, and produce a dendrogram or cluster plot.
Compare a continuous variable between two groups with automatic selection of t-test, Welch test, or Mann-Whitney U test based on data properties.
| name | genome-variant-annotation |
| description | Annotate variants with functional effects using SnpEff or Ensembl VEP, adding gene impact, population frequencies, and clinical significance. |
.vcf.gz).snpeff or vep (default: snpeff).GRCh38).snpEff ann with the appropriate database (e.g., GRCh38.105), producing an annotated VCF and summary stats HTML.vep with --cache, --merged or --refseq, and add plugins (CADD, gnomAD, ClinVar, LOFTEE)..vcf.gz).hg19 when VCF is on GRCh38).