| name | expression-cell-context |
| description | Reconcile gene expression across GTEx, Human Protein Atlas, Bgee, cell atlases, and disease datasets. Use for tissue, cell-type, developmental, baseline-versus-disease, or target-expression questions. |
| license | MIT |
Expression And Cell Context
- Normalize gene, species, transcript, tissue ontology, cell type, disease state, and assay.
- Use GTEx for bulk non-diseased tissue, HPA for tissue/cell protein and RNA context, Bgee for healthy ontology-aware expression, and cellxgene/scRNA workflows for cell-level evidence.
- Keep assay units, normalization, donor/sample counts, batch, tissue composition, release, and detection thresholds separate.
- Distinguish baseline expression, differential expression, eQTL, protein localization, and functional dependence.
- Return concordant and discordant contexts plus experiments that resolve cell-state or assay ambiguity.
Do not infer absence from dropout or portal filtering. Bulk tissue does not identify the expressing cell type; RNA does not guarantee protein abundance or activity.
Save assay-context tables with $science-provenance; use $science-review for cross-assay conclusions.
