| name | clinvar |
| description | Build and inspect ClinVar exact-match evidence and candidate inventories.
Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.
|
| tools | ["genomi.check_libraries","clinvar.match_variants","clinvar.scan_candidates","variant.gather_allele_context","variant.gather_gene_context"] |
| mutating | true |
ClinVar Evidence
Use this skill when the user asks about clinical labels, carrier findings,
pathogenic/likely pathogenic entries, VUS, conflicting classifications, drug
response, risk-factor labels, or ClinVar-derived discovery.
Goal
Build a candidate landscape from exact ClinVar matches. Use
candidate_inventory as variant-level provenance evidence and
candidate_review_groups as the carrier/condition review inventory.
Convention: See skills/conventions/evidence-quality.md.
Contract
- ClinVar matches provide exact/static evidence for source-backed
interpretation.
- Exact matching requires the optional build-specific library
clinvar-grch38 or clinvar-grch37.
- Candidate inventories are variant-level evidence, not interpretation.
- Candidate review groups are review targets. A heterozygous P/LP group can be
carrier-relevance evidence; it is not a carrier-status conclusion.
clinvar.scan_candidates returns an evidence view, grouped support,
warnings, and coverage; use those fields rather than inferring priority from
prose.
