القائمة
Causal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists.
التثبيت باستخدام Codex أو Claude انسخ هذا Prompt والصقه في Codex أو Claude أو مساعد آخر ليراجع صفحة Skill ويثبّتها لك.
Use this skill for genetics, genome source, variant, gene, phenotype, disease, screen, pharmacogenomics, and Genomi install/setup maintenance questions.
Build and inspect ClinVar exact-match evidence and candidate inventories. Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.
Activate this skill for "/genomi decode", "decode my genome", "decode my DNA", "show me the dashboard", "the Genomi dashboard", "one-shot rundown", or any all-at-once request that asks Genomi to compose every capability's findings into a single artifact. This is the whole-genome dashboard kicker — it sweeps every relevant Genomi capability in one shot, not a per-target lookup. Composes evidence from every relevant Genomi capability into a single self-contained Genomi Dashboard.html and returns localhost serve metadata. Active genome required.
Answer drug-response, medication, PharmGKB-style, PGxDB, ATC, DrugBank, gene-drug, and variant-drug questions using public PGx evidence plus local sample genotype support when an Active Genome Index is selected.
Plan rare disease, hereditary disease, cancer risk, carrier-relevance, and observed-condition source investigation from public targets or selected active genome evidence.
Answer specific rsID, allele, gene, region, genotype, and absence/callability questions using explicit session context or public evidence.
استنادا إلى تصنيف SOC المهني
| name | drug-targets |
| description | Causal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists. |
| tools | ["phenotype.retrieve_disease_drug_targets","phenotype.compare_drug_target_evidence","research.list_sources","research.record","research.query","research.search"] |
| mutating | true |
Use this skill for disease-scoped clinical drug-target retrieval, direct drug-target records, PharmaProjects-style target context, ChEMBL mechanism genes, DrugBank target context, or candidate-gene review for a drug, drug class, or mechanism.
prior_fit before reading a panel as task-relevant and audit
decision_evidence before answering.phenotype.retrieve_disease_drug_targets retrieves Open Targets clinical
drug candidate target genes for a supplied disease anchor.phenotype.compare_drug_target_evidence compares candidate genes against direct
drug-side context: drug, drug class, or mechanism.research.list_sources to choose direct target
sources, review them, and store narrow findings with research.record.Example:
phenotype.retrieve_disease_drug_targets with {"disease":"asthma","genes":["ADRB2","IL13"]}phenotype.compare_drug_target_evidence with {"drug_class":"beta agonist","phenotype":"asthma","genes":["ADRB2","IL13"],"source_records":[{"genes":["ADRB2"],"drug_class":"beta agonist","verified_fields":{"genes":["ADRB2"],"drug_class":"beta agonist"},"support_spans":[{"field":"genes","text":"source-backed ADRB2 text"}]}]}Prefer source records with:
genes: candidate target genes named by the source.drug, drug_class, indication, or mechanism.source_title, source_url, and source_type.finding or text: short source-backed finding.verified_fields and support_spans showing where the source supports the
gene and drug-target or mechanism context.Use a direct gene-symbol answer only when reviewed evidence supports the drug-target or mechanism relationship requested by the question. Otherwise state the source gap and summarize the strongest reviewed evidence without presenting it as the final target.
A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.
Compare candidate genes using direct drug-target or mechanism evidence only.
Use when: Returns direct drug-target, target-mechanism, ChEMBL, DrugBank, or PharmaProjects evidence for candidate genes.
Why necessary: Drug-target questions require direct target/mechanism evidence, which is distinct from disease association evidence.
Result semantics: Returns source-local drug-target evidence only; association-only evidence cannot create direct target support.
Retrieve disease-scoped clinical drug-target genes from Open Targets drug candidate records.
Use when: Returns Open Targets clinical drug candidate target genes for a supplied disease anchor, with optional gene_membership projection for supplied candidate genes.
Why necessary: Clinical drug-target records answer therapeutic-target membership without implying causal genetics or treatment efficacy.
Result semantics: Returns disease-scoped clinical drug-target records and source-local ordering; the host agent decides how they apply. mode='gene_membership' projects the same source records into per-gene membership booleans and highest observed phase for supplied genes. Does not ingest agent-supplied evidence and does not infer treatment efficacy or final causal-gene answers.