risk-of-bias-assessment

name	risk-of-bias-assessment
description	Assess methodological bias using RoB2, PROBAST, or QUADAS-2 validated tools
execution	subagent
prompt	./prompt.md
input	study_metadata, study_design
dependencies	{"sops":["spawn-agent"]}

Risk of Bias Assessment SOP

Conduct structured risk-of-bias assessment for individual studies using the appropriate validated tool (RoB 2.0, ROBINS-I, QUADAS-2, PROBAST, or Newcastle-Ottawa Scale).

When to Use

• During quality assessment of each included study
• When deciding sensitivity analysis groupings
• When assessing GRADE certainty (risk of bias domain)

Input

• study_metadata: Study characteristics, methods description, and results
• study_design: The study design (RCT, non-randomized, diagnostic, prediction model, observational)

Output

Domain-level risk-of-bias judgments with supporting rationale for each signaling question.

Available SOPs

Optional, no fixed order; the final leaf is always a sop.

SOP	When to use
spawn-agent	Spawn a customized CC subagent with full MCP tool access. Used by SOPs that declare execution: subagent.