| name | leads-literature-mining |
| description | Review Automator |
| keywords | ["literature-mining","systematic-review","meta-analysis","pubmed","evidence-synthesis"] |
| measurable_outcome | Complete a systematic review screen of 100+ papers with >90% inclusion/exclusion accuracy compared to human baseline. |
| license | CC-BY-4.0 |
| metadata | {"author":"Nature Communications 2025","version":"1.0.0"} |
| compatibility | [{"system":"Python 3.9+"}] |
| allowed-tools | ["run_shell_command","web_fetch"] |
LEADS (Literature Mining Agent)
A specialized LLM agent for automating systematic reviews and meta-analyses, capable of high-accuracy study selection and data extraction.
When to Use
- Systematic Reviews: Screening thousands of abstracts for inclusion criteria.
- Data Extraction: Pulling specific metrics (e.g., hazard ratios, sample sizes) from full-text PDFs.
- Evidence Synthesis: Aggregating findings across multiple studies.
Core Capabilities
- Study Selection: Automated screening based on PICO criteria.
- Data Extraction: Structured extraction of study characteristics and results.
- Quality Assessment: Risk of bias evaluation.
Workflow
- Search: Query PubMed/Embase.
- Screen: Apply inclusion/exclusion criteria to abstracts.
- Extract: Parse full text for data points.
- Report: Generate PRISMA flow diagram and evidence table.
Example Usage
User: "Perform a systematic review on the efficacy of CAR-T in solid tumors."
Agent Action:
python -m leads.review --topic "CAR-T solid tumors" --criteria ./criteria.json