| name | heterogeneity-source-analysis |
| description | Identify and classify sources of between-study heterogeneity (clinical, methodological, statistical) |
| execution | subagent |
| prompt | ./prompt.md |
| input | study_characteristics, effect_sizes, moderator_candidates |
| used-by | meta-analysis |
Heterogeneity Source Analysis SOP
Systematically identify, classify, and prioritize potential sources of between-study heterogeneity for investigation via subgroup analysis and meta-regression.
When to Use
- When meta-analysis reveals substantial heterogeneity (I2 > 50%)
- During planning of subgroup analyses and meta-regression
- When assessing the transitivity assumption in network meta-analysis
Input
study_characteristics: Study-level characteristics and covariates
effect_sizes: Extracted effect sizes showing variation
moderator_candidates: Pre-specified candidate moderator variables
Output
Classified sources of heterogeneity with investigation priority and statistical analysis plan.