boltz-api-skills

Boltz job status and result recovery. Use when listing jobs, checking progress, resuming downloads, recovering results, or downloading an existing job ID. Not for starting new jobs.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

Design new small-molecule binders with Boltz. Use when generating novel ligands or hits for a target without a fixed compound library. Not for screening existing molecules or one-off docking.

Screen existing small-molecule libraries with Boltz. Use when docking, scoring, or ranking a supplied SMILES or compound library against a target; also returns free Tier-1 ADME/ADMET (solubility, permeability, lipophilicity/logD) per molecule. Not for de novo molecule design, one-off docking, or ADME on bare SMILES with no target (use boltz-small-molecule-adme).

Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Boltz job status and result recovery. Use when listing jobs, checking progress, resuming downloads, recovering results, or downloading an existing job ID. Not for starting new jobs.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

Design new small-molecule binders with Boltz. Use when generating novel ligands or hits for a target without a fixed compound library. Not for screening existing molecules or one-off docking.

Screen existing small-molecule libraries with Boltz. Use when docking, scoring, or ranking a supplied SMILES or compound library against a target; also returns free Tier-1 ADME/ADMET (solubility, permeability, lipophilicity/logD) per molecule. Not for de novo molecule design, one-off docking, or ADME on bare SMILES with no target (use boltz-small-molecule-adme).

Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Boltz job status and result recovery. Use when listing jobs, checking progress, resuming downloads, recovering results, or downloading an existing job ID. Not for starting new jobs.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

Design new small-molecule binders with Boltz. Use when generating novel ligands or hits for a target without a fixed compound library. Not for screening existing molecules or one-off docking.

Screen existing small-molecule libraries with Boltz. Use when docking, scoring, or ranking a supplied SMILES or compound library against a target. Not for de novo molecule design or one-off docking.

Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

Boltz CLI setup and auth. Use when installing, updating, verifying, or authenticating `boltz-api`, or fixing missing CLI, PATH, sandbox, browser login, or auth errors.

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

List recent Boltz Compute jobs across all five endpoints, or inspect a single job by ID, and optionally pull its results onto disk. TRIGGER when the user asks what Boltz jobs are running, to check status, whether a screen finished, to resume a prior job, to download results for a job ID, to see how far along a job is, or after a session restart where earlier job IDs were lost.

Generate novel protein binders such as peptides, antibodies, nanobodies, or custom proteins for a target with the Boltz Compute API and return ranked designed sequences with predicted complex structures. TRIGGER when the user wants to design or invent new binders for a target. Not for screening user-supplied proteins and not for small molecules.

Score a user-supplied library of protein sequences against a target with the Boltz Compute API and return ranked binding and structure metrics with per-hit complex structures. TRIGGER when the user wants to rank an existing set of proteins, peptides, antibodies, nanobodies, or binders against a target. Not for designing new proteins and not for small molecules.

Generate novel small-molecule binders for a protein target with the Boltz Compute API and return ranked candidate SMILES with predicted complex structures. TRIGGER when the user wants to design, generate, or propose new ligands or hits for a target and does not already have a compound library. Not for screening user-supplied molecules.

Score a user-supplied SMILES library against a protein target with the Boltz Compute API and return ranked binding and structure metrics with per-hit structures. TRIGGER when the user wants to virtually screen, dock, or rank an existing compound library against a target. Not for designing new molecules and not for a single one-off docking pose.

Predict the 3D structure of a protein, RNA, DNA, or ligand complex with the Boltz Compute API and optionally score binding. TRIGGER when the user asks to fold a complex, dock a ligand, predict an interface, generate a CIF or PDB for a defined system, or get structure and binding metrics for one specified complex. Not for screening libraries or designing new molecules.

List recent Boltz Compute jobs across all five endpoints, or inspect a single job by ID, and optionally pull its results onto disk. TRIGGER when the user asks "what Boltz jobs are running", "check status", "did my screen finish", "resume my job", "download results for <id>", "how far along is <id>", or after a session restart where earlier job IDs were lost.

Generate novel protein binders (peptide, antibody, nanobody, or custom protein) for a target with the Boltz Compute API; returns ranked designed sequences with predicted complex structures. TRIGGER when the user wants to design, generate, propose, or invent new proteins/peptides/antibodies/nanobodies/binders for a target; de novo binder design; antibody/nanobody discovery; peptide design. Not for screening user-supplied proteins (use boltz-protein-screen) and not for small molecules (use boltz-small-molecule-design).

Score a user-supplied library of protein sequences against a target with the Boltz Compute API; returns ranked binding/structure metrics and per-hit complex structures. TRIGGER when the user wants to virtually screen, dock, or rank N existing proteins/peptides/binders/antibodies/nanobodies against a target (FASTA/CSV/sequence list); they have proteins and want to test which bind. Not for designing new proteins (use boltz-protein-design) and not for small molecules (use boltz-small-molecule-screen).

Generate novel small-molecule binders for a protein target with the Boltz Compute API; returns ranked candidate SMILES with predicted complex structures. TRIGGER when the user wants to design, generate, propose, or invent new small molecules / ligands / hits for a target (no existing library); de novo small molecule discovery; lead generation. Not for screening user-supplied molecules (use boltz-small-molecule-screen).

Score a user-supplied SMILES library against a protein target with the Boltz Compute API; returns ranked binding/structure metrics and per-hit structures. TRIGGER when the user wants to virtually screen, dock, or score N existing compounds against a target (CSV/SMI/SMILES list); they have molecules and want to rank them. Not for generating new molecules and not for a single docking pose (use boltz-structure-and-binding for one ligand).

Predict the 3D structure of a protein/RNA/DNA/ligand complex with the Boltz Compute API and (optionally) score binding. TRIGGER when the user asks to fold a complex, dock a ligand, predict an interface, get a CIF/PDB file for a sequence + ligand, get pTM/ipTM/pLDDT/binding_confidence/optimization_score for a defined system. Not for screening libraries or designing new molecules.