ALWAYS load when working in pwiz_tools/Osprey (C# port), on maccoss/osprey (Rust), or debugging Osprey-Rust parity issues.
ALWAYS load before git commit, push, or PR - team-specific commit format differs from standard conventions.
ALWAYS load when working on LabKey Server modules (MacCossLabModules, targetedms), in a LabKey enlistment directory, or on GitHub issues/PRs in LabKey repositories.
ALWAYS load when working in pwiz_tools/Skyline, on GitHub issues labeled 'skyline', or TODOs referencing Skyline code.
Invoke when starting an autonomous overnight session ("this is a nighttime autonomous session"). Sets a deep-investigation posture - premium on progress and high-definition findings, expects 5-8 hours of work without check-ins.
ALWAYS load when investigating bugs, failures, or unexpected behavior - ensures root cause analysis before attempting fixes.
Load when investigating handle leaks, memory leaks, or GC-LEAK failures. Covers handle counting, dotMemory profiling, and GC leak tracker workflows.
Use this skill when reviewing or updating tutorial screenshots.