drug-target-report

name	drug-target-report
description	Druggability assessment — protein function, 3D structures, ligand-bound PDBs, binding sites, interaction network, disease associations, and literature

Generate a druggability and drug-target assessment report for: $ARGUMENTS

Use the MCP tools to gather data from all relevant sources, then synthesize a structured drug-target report. Follow the steps below in order. If a step fails or returns no data, note the gap and continue.

Input Parsing

Determine the input type:

1. UniProt accession (e.g., P00533) — use directly
2. Gene symbol (e.g., EGFR) — resolve to UniProt accession
3. Protein name — search UniProt

Data Gathering Steps

1. Target Identity & Function

• If input is a gene symbol or name, call uniprot_search with the query and organism_id:9606 (reviewed: true).
• Call uniprot_get_protein with the accession to get:
  • Function description, catalytic activity (enzyme classification)
  • GO terms (molecular function — look for kinase, receptor, enzyme, transporter, channel, protease activities)
  • Subcellular localization (membrane, extracellular, cytoplasmic — affects drug accessibility)
  • Tissue specificity
• Call datasets_summary_gene with the gene symbol for NCBI summary and aliases.

2. Domain Architecture & Functional Sites

• Call interpro_get_domains with the UniProt accession.
• Call uniprot_get_features with the UniProt accession to get all features.
• Identify druggable features:
  • — enzymatic targets