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ic50-fit

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Aktualisiert8. Mai 2026 um 08:57

Fit dose-response curves and calculate IC50/EC50 with confidence intervals using 4-parameter logistic regression.

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yejunbin/darwin

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Verwandte BerufeSOC

Basierend auf der SOC-Berufsklassifikation

DatenwissenschaftlerInformatik- und Mathematikberufe·SOC 15-2051

SKILL.md

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name	ic50-fit
description	Fit dose-response curves and calculate IC50/EC50 with confidence intervals using 4-parameter logistic regression.

IC50 / EC50 Fitting

Fit dose-response curves with nonlinear regression.

Model

4-parameter logistic (4PL):

response = bottom + (top - bottom) / (1 + 10^((logIC50 - logConc) * hillSlope))

Software

Python: scipy.optimize.curve_fit
R: drc package (drm function)
GraphPad Prism (reference standard)

Validation

R² or pseudo-R²
Residual analysis
Visual inspection
Comparison with literature values

Output

# Dose-Response: [compound]

## Fitted Parameters
| Parameter | Estimate | 95% CI | SE |
|-----------|----------|--------|-----|
| IC50/EC50 | ... | ... | ... |
| Hill Slope | ... | ... | ... |
| Top | ... | ... | ... |
| Bottom | ... | ... | ... |

## Model Quality
- R²: ...
- Residuals: ...

## Script
[Attach analysis script]

## Plot
[Attach dose-response plot]

Save to outputs/ic50-<slug>.md with script and plot.

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name	ic50-fit
description	Fit dose-response curves and calculate IC50/EC50 with confidence intervals using 4-parameter logistic regression.

IC50 / EC50 Fitting

Fit dose-response curves with nonlinear regression.

Model

4-parameter logistic (4PL):

response = bottom + (top - bottom) / (1 + 10^((logIC50 - logConc) * hillSlope))

Software

Python: scipy.optimize.curve_fit
R: drc package (drm function)
GraphPad Prism (reference standard)

Validation

R² or pseudo-R²
Residual analysis
Visual inspection
Comparison with literature values

Output

# Dose-Response: [compound]

## Fitted Parameters
| Parameter | Estimate | 95% CI | SE |
|-----------|----------|--------|-----|
| IC50/EC50 | ... | ... | ... |
| Hill Slope | ... | ... | ... |
| Top | ... | ... | ... |
| Bottom | ... | ... | ... |

## Model Quality
- R²: ...
- Residuals: ...

## Script
[Attach analysis script]

## Plot
[Attach dose-response plot]

Save to outputs/ic50-<slug>.md with script and plot.