| name | open-targets-platform |
| description | Query the Open Targets Platform for drug-target-disease associations. Use whenever the user asks about drug targets, gene-disease associations, drug indications, clinical trial phases, or wants to look up any entity (Ensembl gene ID, ChEMBL drug ID, or free-text gene/drug name) in Open Targets. Also trigger when the user mentions Open Targets, ENSG IDs, CHEMBL IDs, or asks about target prioritization for diseases.
|
Open Targets Platform Query Skill
Query the Open Targets GraphQL API for drug, target, and disease association data. No API key required.
Entity Auto-Detection
| Input Pattern | Detected As | Example |
|---|
ENSG00000... | Target (Ensembl gene ID) | ENSG00000146648 (EGFR) |
CHEMBL... | Drug (ChEMBL ID) | CHEMBL941 (Imatinib) |
| anything else | Free-text search | BRCA1, aspirin |
API
| Function | Input | Returns |
|---|
query(entity) | single entity string | dict with type, name, associations |
query_batch(entities) | list of entity strings | list[dict] |
summarize(result) | query result dict | compact one-line text |
get_target_info(ensembl_id) | Ensembl ID string | raw GraphQL response |
get_drug_info(chembl_id) | ChEMBL ID string | raw GraphQL response |
search_entities(term) | free-text string | raw GraphQL response |
Return Format
Target result:
{"entity": "ENSG00000146648", "type": "target", "found": true,
"symbol": "EGFR", "name": "epidermal growth factor receptor",
"biotype": "protein_coding",
"top_diseases": [{"disease": "lung carcinoma", "score": 0.78}]}
Drug result:
{"entity": "CHEMBL941", "type": "drug", "found": true,
"name": "IMATINIB", "drug_type": "Small molecule",
"max_phase": 4,
"indications": [{"disease": "chronic myeloid leukemia", "phase": 4}]}
Search result:
{"entity": "BRCA1", "type": "search", "found": true,
"hits": [{"id": "ENSG00000012048", "name": "BRCA1", "entity_type": "target"}]}
Usage
See if __name__ == "__main__" block in 12_Open_Targets_Platform.py for runnable examples covering: single target/drug/search query, batch query, and JSON output.
Source
