DrugClaw

Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.

Query canonical DrugCombDB combination records. Use when the user asks about drug pairs, synergy values, or cell-line-specific combination evidence.

Query or inspect the FDA Orange Book - FDA-Approved Drug Products Listing resource for drug-centric tasks with emphasis on drug knowledgebase Use whenever Codex needs the calling pattern, downloadable entrypoint, or example query flow from this skill example script.

Query the RepurposeDrugs single-agent drug repurposing database. Use whenever the user asks about drug-disease repurposing associations, clinical trial phases for repurposed drugs, or wants to look up any entity (drug name, disease name, NCT ID) in RepurposeDrugs.

Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.

Query canonical TarKG drug-target triplets. Use when the user asks about drug-target interactions, relation labels, disease/pathway context, or quick lookups for drugs/targets in TarKG.

Query the MecDDI mechanism-based drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI mechanisms (PK/PD), enzyme or transporter-mediated interactions, or wants to look up interacting drug pairs by drug name or MecDDI drug ID. Trigger on keywords like DDI, drug interaction, MecDDI, mechanism-based interaction, pharmacokinetic interaction, pharmacodynamic interaction, or any query involving two drugs that may interact.

Query the DrugMechDB drug mechanism-of-action database. Use whenever the user asks about drug mechanisms, drug-to-disease paths, biological targets of a drug, or wants to look up any biomedical entity (drug name, protein, disease, DrugBank ID, MESH ID, UniProt ID, GO term, etc.) in DrugMechDB.

Query the CADEC (CSIRO Adverse Drug Event Corpus). Use whenever the user asks about adverse drug event mentions in consumer health text, entity annotations from patient forum posts, MedDRA/SNOMED-CT normalised ADR spans, or wants to look up drugs, symptoms, or coded entities in the CADEC corpus.

Query the PsyTAR psychiatric adverse-reaction corpus. Use when the user asks about patient-reported ADRs, withdrawal symptoms, drug indications, or effectiveness for Zoloft, Lexapro, Cymbalta, or Effexor XR. Accepts drug names (brand or generic), symptom terms, or UMLS CUIs.

Query the DrugRepoBank drug repurposing evidence database. Use whenever the user asks about repurposing candidates, drug–disease–target repurposing evidence, or wants to look up any entity (drug name, DrugBank ID, ChEMBL ID, PubChem CID, TTD target ID, UniProt ID, disease name) in DrugRepoBank.

Query the OREGANO knowledge graph for computational drug repurposing. Use whenever the user asks about drug–target–disease–gene–pathway relationships, compound cross-references, drug repurposing hypotheses, or wants to explore neighbors of any biomedical entity in a knowledge graph that includes natural compounds.

Query the RepoDB drug repurposing database. Use whenever the user asks about drug-disease associations, drug repurposing candidates, or wants to look up any entity (drug name, indication, DrugBank ID, UMLS CUI, NCT ID) in RepoDB.

Query the Broad Institute Drug Repurposing Hub (~6,800 compounds). Look up drugs by name, gene target, MOA, disease area, Broad ID, or InChIKey. Returns clinical phase, mechanism of action, targets, disease area, indication, and chemical identifiers.

Query the DrugLib.com Drug Review Dataset (UCI #461). Use whenever the user asks about patient drug reviews, drug effectiveness ratings, side-effect profiles, or condition-specific treatment experiences from DrugLib.com.

Query the WebMD Drug Reviews dataset (~362 k patient reviews, 2007–2020). Use whenever the user asks about patient-reported drug effectiveness, ease of use, satisfaction ratings, side effects, or reviews for a specific drug or medical condition.

Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.

Query the UniTox drug toxicity database. Use whenever the user asks about organ-system toxicity ratings for a drug, multi-organ toxicity profiles, or wants to look up any entity (drug name, SMILES, SPL_ID) in UniTox.

Query the Therapeutic Target Database (TTD) for drug-target-disease interaction data. Use this skill when the user asks about therapeutic targets, drugs, diseases, or their relationships — including target-drug mappings, clinical status of drugs, disease indications, UniProt/gene associations, and pathway annotations. Triggers on queries like "what drugs target EGFR", "which diseases is Imatinib used for", "find targets for lung cancer", or any lookup involving TTD IDs, gene symbols, drug names, or disease names.

Query the DDInter drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI severity levels, or wants to look up interactions for a drug name or DDInter ID.

Query FDA drug labeling data via openFDA. Use whenever the user asks about drug prescribing information — indications, warnings, dosage, adverse reactions, contraindications, or administration routes. Supports single or batch lookup by brand/generic name or by indication/condition.

Query the ChEMBL database for drug molecules, bioactivity data, and drug targets via the ChEMBL REST API. Use whenever the user asks about drug properties (molecular weight, logP, Lipinski violations), drug-target interactions, bioactivity assay results, or wants to look up any entity by ChEMBL ID or drug/gene name in ChEMBL. Supports single entity or batch queries. No API key required.

Query the DrugCentral drug pharmacology database. Use whenever the user asks about approved drug structures, drug targets, pharmacological actions, or wants to look up any entity (drug name, DrugCentral ID, CAS number, InChIKey) in DrugCentral.

Query the Open Targets Platform for drug-target-disease associations. Use whenever the user asks about drug targets, gene-disease associations, drug indications, clinical trial phases, or wants to look up any entity (Ensembl gene ID, ChEMBL drug ID, or free-text gene/drug name) in Open Targets. Also trigger when the user mentions Open Targets, ENSG IDs, CHEMBL IDs, or asks about target prioritization for diseases.

Query a locally downloaded DrugBank database. Use whenever the user asks about drug information, drug targets, drug-drug interactions, drug categories, or wants to look up any entity (DrugBank ID, drug name, CAS number, synonym) in DrugBank.

Query the ADReCS (Adverse Drug Reaction Classification System) v3.3 database. Use whenever the user asks about adverse drug reactions, drug safety profiles, ADR classification, ADR severity/frequency, or wants to look up any entity (drug name, BADD Drug ID, DrugBank ID, ATC code, CAS RN, PubChem CID, KEGG ID, ADR term, ADReCS ID, MedDRA code, MeSH ID) in ADReCS.

Query the nSIDES drug side effect databases (OnSIDES, OffSIDES, KidSIDES). Use whenever the user asks about drug adverse reactions, side effects, off-label safety signals, or pediatric drug safety for a given drug name.

Query the PharmKG knowledge graph (180k entities, 39 relation types, >1M triples). Use whenever the user asks about biomedical relationships among genes, drugs/chemicals, and diseases — e.g. drug–gene interactions, drug–disease associations, gene–disease links, or drug–drug relationships derived from literature and curated databases.

Query the WHO Model List of Essential Medicines (23rd list, 2023). Use whenever the user asks about essential medicines, WHO-recommended drugs, dosage forms, therapeutic sections, or AWaRe antibiotic classification.

Query the PHEE pharmacovigilance event extraction dataset. Use whenever the user asks about annotated adverse drug events, pharmacovigilance case reports, drug–effect associations from medical literature, or wants to find PHEE examples mentioning a drug name, adverse effect, or condition.

Query TAC 2017 ADR annotated drug labels for adverse drug reactions. Use whenever the user asks about ADRs extracted from FDA drug labels, MedDRA-normalized adverse reactions, or wants to look up a drug name, ADR string, or MedDRA code in the TAC 2017 ADR corpus.

Query the WHO ATC/DDD Classification System. Use whenever the user asks about ATC codes, drug classification hierarchy, Defined Daily Doses (DDD), or wants to look up drugs by ATC class or find the ATC code for a drug name.

Query the DRKG (Drug Repurposing Knowledge Graph). Use whenever the user asks about drug–gene, drug–disease, gene–disease, or other biomedical entity relationships in a knowledge-graph context, drug repurposing candidates, COVID-19 drug repurposing, or wants to explore neighbours of any biomedical entity (compound, gene, disease, pathway, side effect, etc.) in DRKG.

Query the NCI-60 Molecular Target (Protein) database from the Developmental Therapeutics Program. Use when the user asks about protein expression of drug targets across the NCI-60 cancer cell line panel, or wants to look up a gene, cell line, or cancer panel in the NCI DTP molecular target dataset.

Query the FDA Adverse Event Reporting System (FAERS) via openFDA API. Use whenever the user asks about adverse drug reactions, side effects, drug safety signals, or wants to look up reported adverse events for one or more drug names.

Query the IUPHAR/BPS Guide to Pharmacology REST API for drug targets, ligands (drugs/compounds), and their interactions. Use whenever the user asks about pharmacological targets, receptor–ligand relationships, drug mechanisms of action, or wants to look up any drug or target name in IUPHAR. Supports single entity or batch queries. No API key required.

Query DailyMed for FDA drug label / package insert information. Use whenever the user asks about drug labeling, SPL documents, prescribing information, NDC codes, or needs to look up current FDA-approved drug details by name or NDC. Supports single entity or batch queries.

Query MedlinePlus for consumer-oriented drug and health-topic information. Accepts drug names, RxCUI codes, NDC codes, or ICD-10-CM diagnosis codes. Uses two free, keyless NLM APIs: the Web Service (keyword search) and MedlinePlus Connect (code-based lookup).

Query the ChEBI (Chemical Entities of Biological Interest) database. Use whenever the user asks about small molecule identifiers, chemical ontology roles, molecular formulae, SMILES, InChI, synonyms, or cross-references for biologically relevant chemical compounds via ChEBI.

Query NDF-RT (National Drug File Reference Terminology) via the NCI EVS REST API. Use when looking up drug mechanisms of action, physiological effects, pharmacologic classes, chemical structures, or drug–disease relationships (may_treat / may_prevent) in NDF-RT. Accepts drug names or NDF-RT codes.