Développeurs de logiciels Fast TCR/BCR FR/CDR region annotation (Antigen Receptor Domain Annotation). Use whenever the user wants to annotate immune-receptor sequences with framework/CDR regions, V/D/J gene calls, constant-region isotype (c_call/c_class), junction/CDR3 boundaries, or AIRR output — for TCR (TRA/TRB/TRG/TRD) or BCR (IGH/IGK/IGL), nucleotide or amino acid, single sequences or large FASTA/FASTQ. Also use for: marking up, validating or REPAIRING a bare (CDR3 amino acid, V, J) record that has no read behind it — a VDJdb-style row — including locating where it disagrees with germline and restoring a missing Cys104 / Phe118 anchor; calling the D gene (and tandem D-D) on a bare junction, or inferring it from junction length when the protein shows none of it; extracting the receptor repertoire (clonotypes, isotype usage) from bulk RNA-seq; getting germline FR1-FR3/CDR1-CDR2 (V) or FR4 (J) subsequences for individual alleles; building or rebuilding the reference database from IMGT germlines via IgBLAST; or diagnosing mmseqs2 set
2026-07-14