nccn-b-cell-lymphomas

name	nccn-b-cell-lymphomas
description	NCCN clinical practice guideline navigation for B-Cell Lymphomas. Use when a clinician needs treatment decisions, staging, workup, or evidence for B-Cell Lymphomas based on NCCN Guidelines version 3.2025.
metadata	{"author":"nccn-skill-generator","version":"3.2025","source":"NCCN Clinical Practice Guidelines in Oncology","guideline":"B-Cell Lymphomas"}
license	See NCCN terms of use

NCCN Guidelines: B-Cell Lymphomas

Clinical decision support derived from NCCN Clinical Practice Guidelines in Oncology. Version 3.2025.

Indolent Lymphomas

Follicular Lymphoma

• Algorithm: Follicular Lymphoma -- Staging, workup, and treatment pathways
• Evidence: Follicular Lymphoma -- Discussion of clinical evidence and rationale

Marginal Zone Lymphomas

• Algorithm: Marginal Zone Lymphomas -- Staging, workup, and treatment pathways
• Evidence: Marginal Zone Lymphomas -- Discussion of clinical evidence and rationale

Histologic Transformation of Indolent Lymphomas to DLBCL

• Algorithm: Histologic Transformation of Indolent Lymphomas to DLBCL -- Staging, workup, and treatment pathways
• Evidence: Histologic Transformation of Indolent Lymphomas to DLBCL -- Discussion of clinical evidence and rationale

Aggressive Lymphomas

Mantle Cell Lymphoma

• Algorithm: Mantle Cell Lymphoma -- Staging, workup, and treatment pathways
• Evidence: Mantle Cell Lymphoma -- Discussion of clinical evidence and rationale

Primary Mediastinal Large B-Cell Lymphoma

• Algorithm: Primary Mediastinal Large B-Cell Lymphoma -- Staging, workup, and treatment pathways
• Evidence: Primary Mediastinal Large B-Cell Lymphoma -- Discussion of clinical evidence and rationale

HGBL-NOS (ICC and WHO5)

• Algorithm: HGBL-NOS (ICC and WHO5) -- Staging, workup, and treatment pathways

HGBL with MYC and BCL2 rearrangements with or without BCL6 rearrangements

• Algorithm: HGBL with MYC and BCL2 rearrangements with or without BCL6 rearrangements -- Staging, workup, and treatment pathways

Burkitt Lymphoma

• Algorithm: Burkitt Lymphoma -- Staging, workup, and treatment pathways
• Evidence: Burkitt Lymphoma -- Discussion of clinical evidence and rationale

Treatment Options for Stage II (noncontiguous, bulky) and Stage III–IV MCL

• Evidence: Treatment Options for Stage II (noncontiguous, bulky) and Stage III–IV MCL -- Discussion of clinical evidence and rationale

Diffuse Large B-Cell Lymphomas

• Evidence: Diffuse Large B-Cell Lymphomas -- Discussion of clinical evidence and rationale

ALK-Positive Large B-Cell Lymphomas

• Evidence: ALK-Positive Large B-Cell Lymphomas -- Discussion of clinical evidence and rationale

Mediastinal Gray Zone Lymphomas

• Evidence: Mediastinal Gray Zone Lymphomas -- Discussion of clinical evidence and rationale

High-Grade B-Cell Lymphomas

• Evidence: High-Grade B-Cell Lymphomas -- Discussion of clinical evidence and rationale

Disease Subtypes

Lymphoblastic Lymphoma

• Algorithm: Lymphoblastic Lymphoma -- Staging, workup, and treatment pathways

Special Populations

HIV-Related B-Cell Lymphomas

• Algorithm: HIV-Related B-Cell Lymphomas -- Staging, workup, and treatment pathways
• Evidence: HIV-Related B-Cell Lymphomas -- Discussion of clinical evidence and rationale

Post-Transplant Lymphoproliferative Disorders

• Algorithm: Post-Transplant Lymphoproliferative Disorders -- Staging, workup, and treatment pathways
• Evidence: Post-Transplant Lymphoproliferative Disorders -- Discussion of clinical evidence and rationale

Shared Resources

Diagnosis

• Diagnosis -- Initial evaluation and diagnostic workup

Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Ne

• Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Ne -- Initial evaluation and diagnostic workup

Supportive Care for B-Cell Lymphomas

• Supportive Care for B-Cell Lymphomas -- Supportive care guidelines

Lugano Response Criteria for Non-Hodgkin Lymphoma

• Lugano Response Criteria for Non-Hodgkin Lymphoma -- Standardized response assessment criteria

Principles of Radiation Therapy

• Principles of Radiation Therapy -- Radiation therapy guidelines

Guidance for Treatment of Patients with Chimeric Antigen Receptor (CAR) T-Cell Therapy

• Guidance for Treatment of Patients with Chimeric Antigen Receptor (CAR) T-Cell Therapy -- Shared clinical resource

Overview

• Overview -- Shared clinical resource

Guidelines Update Methodology

• Guidelines Update Methodology (Evidence) -- Shared clinical resource

Sensitive/Inclusive Language Usage

• Sensitive/Inclusive Language Usage (Evidence) -- Shared clinical resource

Supportive Care

• Supportive Care -- Supportive care guidelines

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Citation: NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas, Version 3.2025. National Comprehensive Cancer Network. Available at nccn.org.

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