next-data-variant-confidence

name	next-data-variant-confidence
kind	standing
domain	next_data
description	Uncertainty-ranked gap report (spec §8b). For an unresolved (Tier B) variant, names that the analysis can't resolve it and attributes the gap to a missing input — a documented family history — that would let the analysis weight it. Never a test order.

next-data-variant-confidence

A standing next-data specialist (spec §8b), a DIFFERENT objective from next-data-pgx-coverage: it optimizes over variant uncertainty. For each Tier B (uncertain-significance) variant on the profile, when no family history is on file, it emits a next_data EvidenceRecord in the required frame:

"The analysis currently can't resolve the uncertain variant {gene} {hgvs}; the input that would most change this is a documented family history of the condition, which would let the analysis weight it — moving it from uncertain toward classifiable."

Deterministic: it reuses clinvar.lookup to find Tier B variants and checks whether family history is present. Same code gate invariant — names a limitation, a missing input, and how much closing it helps; never "you should get tested".

Entrypoint: specialist.run_specialist(profile, ctx).