drug-safety-review

name	drug-safety-review
description	Comprehensive medication safety review system providing real-time analysis of drug-drug interactions, contraindications, allergy risks, and dosing optimization. Supports 20,000+ FDA-approved medications with 200,000+ documented interactions. Features evidence-based recommendations to prevent adverse drug events and optimize therapeutic outcomes.

Drug Safety Review

AI-powered medication safety review system for healthcare providers, pharmacists, and patients. Provides comprehensive drug safety analysis including interactions, contraindications, allergies, and dosing optimization.

Features

1. Drug-Drug Interaction Detection - 200,000+ documented interaction pairs
2. Contraindication Analysis - Absolute and relative contraindications
3. Allergy Detection - Drug and excipient allergy screening
4. Dosing Optimization - Renal, hepatic, and age-based adjustments
5. Monitoring Recommendations - Lab tests and clinical monitoring
6. Alternative Therapy Suggestions - Safer medication alternatives

Quick Start

Review medication safety:

from scripts.safety_review import review_medications
import os

# Set environment variables
os.environ["SKILL_BILLING_API_KEY"] = "your-api-key"
os.environ["SKILL_ID"] = "your-skill-id"

# Review patient medications
result = review_medications(
    medications=[
        {"drug": "warfarin", "dose": "5mg", "frequency": "daily"},
        {"drug": "amoxicillin", "dose": "500mg", "frequency": "q8h"}
    ],
    allergies=[
        {"allergen": "penicillin", "reaction": "anaphylaxis"}
    ],
    patient_data={
        "age": 65,
        "weight": 75,
        "renal_function": {"egfr": 45}
    },
    user_id="user_123"
)

# Check result
if result["success"]:
    print("安全状态:", result["safety_status"])
    print("警报数量:", len(result["alerts"]))
    for alert in result["alerts"]:
        print(f"- [{alert['severity']}] {alert['title']}")
else:
    print("错误:", result["error"])
    if "paymentUrl" in result:
        print("充值链接:", result["paymentUrl"])

API Usage:

# Set environment variables
export SKILL_BILLING_API_KEY="your-api-key"
export SKILL_ID="your-skill-id"

# Run safety review
python scripts/safety_review.py \
  --medications '[{"drug":"warfarin","dose":"5mg"}]' \
  --allergies '[{"allergen":"penicillin"}]' \
  --patient '{"age":65}' \
  --user-id "user_123"

Configuration

• Provider: skillpay.me
• Pricing: 1 token per call (~0.001 USDT)
• Minimum deposit: 8 USDT
• API Key: SKILL_BILLING_API_KEY environment variable
• Skill ID: SKILL_ID environment variable

Alert Severity Levels

Level	Name	Description	Action
1	Critical	Life-threatening, immediate action required	Avoid combination
2	Major	Significant risk, strong recommendation	Consider alternatives
3	Moderate	Potential risk, monitoring required	Monitor closely
4	Minor	Limited clinical significance	Routine monitoring

Supported Drug Classes

• Cardiovascular: Anticoagulants, antiarrhythmics, antihypertensives
• CNS Drugs: Antidepressants, antipsychotics, antiepileptics, opioids
• Infectious Disease: Antibiotics, antifungals, antiretrovirals
• Oncology: Chemotherapeutic agents, targeted therapies
• Endocrine: Diabetes medications, thyroid hormones
• GI Drugs: PPIs, H2 blockers, laxatives
• Respiratory: Bronchodilators, corticosteroids
• Pain Management: NSAIDs, acetaminophen, muscle relaxants

References

• Drug database: references/drug-database.md
• Interaction criteria: references/interaction-criteria.md
• Billing API: references/skillpay-billing.md

Disclaimer

This tool is for clinical decision support only and does not replace professional pharmacist or physician judgment. Always verify recommendations with qualified healthcare providers.

System Limitations:

• Not a substitute for clinical judgment
• Accuracy depends on complete medication and allergy data
• Rare interactions may have limited data
• Patient-specific factors may affect actual risk