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O SkillsMP coletou 605 skills de aipoch/medical-research-skills. Abra uma skill para revisar a origem e os detalhes.
aipoch/medical-research-skillsMostrando 40 de 605 skills coletadas.
Design scientific experiments including sample size calculation, randomization, control groups, blinding, and study protocols. Covers RCTs, quasi-experiments, factorial designs, A/B tests, survey design, and observational studies. Use when user asks to design…
Idioma do texto original: inglês
Structured scientific hypothesis formulation from observations; use when you have experimental observations or preliminary data and need testable hypotheses with predictions, mechanisms, and validation experiments.
Idioma do texto original: inglês
Generate and optimize clinical trial subject inclusion/exclusion criteria to balance scientific rigor with recruitment feasibility.
Idioma do texto original: inglês
Generates a PROSPERO-compliant Meta-analysis protocol based on Title and PICOS. Use when the user wants to write a protocol for a systematic review or meta-analysis.
Idioma do texto original: inglês
Assists researchers in generating PROSPERO registration content for meta-analyses from a title and optional protocol. Use when the user wants to draft a PROSPERO registration form.
Idioma do texto original: inglês
Standardize fragmented experimental steps into reproducible protocol documents when you need method organization, lab SOP drafting, or cross-operator reproducibility; missing parameters must be explicitly marked as "To be supplemented/Not provided".
Idioma do texto original: inglês
Generates randomization sequences for RCTs including simple, blocked, and stratified allocation. Produces sealed randomization lists ready for allocation concealment.
Idioma do texto original: inglês
Generates a comprehensive research proposal design based on input literature, including hypothesis, mechanism verification, and budget. Use when the user wants to design a research project from a paper.
Idioma do texto original: inglês
Basic sample size estimator for clinical research planning. Computes per-group and total N for two-sample/paired t-tests, chi-square tests, and proportion comparisons, reporting alpha, power, effect size, and statistical assumptions summary for grant…
Idioma do texto original: inglês
Write GCP-compliant standard operating procedures for laboratory, clinical, or research workflows; use when a reproducible SOP with roles, steps, and control points is required.
Idioma do texto original: inglês
Strategic clinical trial design feasibility assessment using ToolUniverse. Evaluates patient population sizing, biomarker prevalence, endpoint selection, comparator analysis, safety monitoring, and regulatory pathways. Creates comprehensive feasibility…
Idioma do texto original: inglês
A comprehensive auditor for any agent skill — including Manus, OpenClaw/ClawHub, Claude, LobeHub, or custom SKILL.md-based skills. Use this skill whenever a user wants to evaluate, audit, review, score, or quality-check an agent skill before publishing,…
Idioma do texto original: inglês
Run GSEA on a ranked gene list and produce the enrichment table, running-score table, and enrichment plots.
Idioma do texto original: inglês
Identifies real, evidence-audited, topic-specific research gaps in medical research by first retrieving and verifying literature from trusted sources, then mapping the current evidence landscape, rejecting pseudo-gaps, and converting only…
Idioma do texto original: inglês
Converts an audited medical research gap into a complete, structured, gap-traceable study design. Always use this skill whenever a user already has one or more candidate research gaps and wants to transform them into an executable biomedical research plan…
Idioma do texto original: inglês
Evidence-based medical knowledge and research mentor grounded in the Bian Que tradition. Covers clinical reasoning, diagnostic thinking (望闻问切), pharmacology, pathology, differential diagnosis, medical literature appraisal, and the philosophy of early…
Idioma do texto original: inglês
Use when correcting batch effects in merged bulk expression matrices with sample-level batch metadata while preserving biological group structure and generating before-and-after QC plots. NOT for: single-cell integration, raw FASTQ processing, differential…
Idioma do texto original: inglês
Use when building a ceRNA regulatory network from a key gene list by combining bundled miRNA-mRNA and miRNA-lncRNA database files, with flat-file CSV exports and PDF visualization in a single output directory. NOT for: differential expression, single-cell…
Idioma do texto original: inglês
Use when evaluating the clinical utility of a binary prediction model from a single clinical CSV file by fitting a logistic decision-curve model, plotting decision and clinical-impact curves, and exporting summary outputs. NOT for: survival calibration,…
Idioma do texto original: inglês
Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path and cross-validation plots. Trigger keywords: elastic net,…
Idioma do texto original: inglês
Use this skill to compute ESTIMATE immune-related microenvironment scores from a bulk expression matrix, generate an ESTIMATE score heatmap, and optionally generate group-wise ESTIMATE score boxplots plus significance tables when a sample group file is…
Idioma do texto original: inglês
Use when validating an existing prognostic risk signature on an external bulk expression cohort with survival outcomes, producing risk scores, Kaplan-Meier curves, risk distribution plots, heatmap, and time-dependent ROC curves. NOT for: model training,…
Idioma do texto original: inglês
Use this skill to run GSVA or ssGSEA pathway-level differential analysis from a bulk expression matrix and a sample group file, then generate a heatmap from the saved GSVA result object. Trigger keywords: GSVA, ssGSEA, pathway enrichment, KEGG pathway…
Idioma do texto original: inglês
Use when building a sample-level hierarchical clustering dendrogram from a bulk expression matrix and sample annotation table, especially for QC, batch inspection, or sample similarity assessment. Trigger keywords: hierarchical clustering, dendrogram, sample…
Idioma do texto original: inglês
Use when filtering genes with high missingness and then imputing missing values in a bulk expression matrix with group-aware KNN through DMwR2, where donor samples are restricted by one annotation column before imputation. For strata with 10 or fewer samples,…
Idioma do texto original: inglês
Use when building a binary classification model from an expression matrix or other omics feature matrix with LASSO logistic regression, cross-validation, and coefficient path visualization. NOT for: multiclass classification, survival/Cox models, or ordinary…
Idioma do texto original: inglês
Use when assessing how well a survival model's predicted probabilities agree with observed outcomes by fitting a Cox model and generating bootstrap calibration curves at one or more prediction horizons from a clinical CSV file. NOT for: nomogram construction,…
Idioma do texto original: inglês
Use when constructing a prognosis nomogram from survival-related clinical predictors, exporting the nomogram bundle and C-index table, and optionally rendering the final nomogram PDF. NOT for: univariate/multivariable Cox feature screening, calibration…
Idioma do texto original: inglês
Use when evaluating diagnostic biomarker performance from case-control expression data with logistic regression and ROC curves, exporting coefficient and AUC tables together with a ROC PDF. NOT for: survival analysis, time-to-event outcomes, multiclass…
Idioma do texto original: inglês
Use when generating Sankey or alluvial plots from sample annotation tables where rows are samples and selected columns are categorical stages such as risk group, response status, subtype, or cohort labels. NOT for: gene network flow analysis, continuous-value…
Idioma do texto original: inglês
Use when analyzing transcription factor (TF) regulatory networks using Dorothea database. Input gene list, identify regulating transcription factors, generate TF-Target network visualization. For: transcription factor enrichment analysis, gene regulatory…
Idioma do texto original: inglês
Use when performing sample-level dimensionality reduction and visualization on abundance or OTU-style matrices with a companion group file, generating UMAP and/or t-SNE coordinates and plots for group separation assessment. NOT for: differential expression…
Idioma do texto original: inglês
Use when running prognostic survival analysis on a clinical cohort with time-to-event data to estimate univariate and multivariable Cox proportional hazards models, export result tables, and generate forest plots. NOT for: nomogram construction, calibration…
Idioma do texto original: inglês
Run a submission-readiness preflight on a manuscript before arXiv upload. Use when the user is preparing an arXiv submission, asks to check a paper before uploading, mentions hallucinated or fake references, leftover LLM meta-comments / prompts in text,…
Idioma do texto original: inglês
Use when analyzing bulk RNA-seq or microarray expression data to identify differentially expressed genes between two biological groups (case vs control), with volcano plots and heatmap visualization. NOT for:single-cell RNA-seq, methylation analysis,…
Idioma do texto original: inglês
Reads a paper figure by figure before re-integrating the full narrative, so the user can identify the core findings quickly and check whether each visual actually supports the authors' main claims. Always separate figure content, figure-linked claim,…
Idioma do texto original: inglês
Academic paper reading and research development system for biomedical researchers. Finds papers via Semantic Scholar, reads with structured notes, tracks discussion insights, and synthesizes literature into a Research Foundation Document (RFD) for downstream…
Idioma do texto original: inglês
A medical-research-native literature reading skill for users with clinical, bioinformatics, translational, and basic experimental backgrounds. Use this skill whenever a user wants to read, analyze, critique, or interpret a medical or scientific paper —…
Idioma do texto original: inglês
Use this skill when converting academic papers to promotional and presentation formats, including interactive websites (Paper2Web), presentation videos (Paper2Video), and conference posters (Paper2Poster). This skill is suitable for paper dissemination,…
Idioma do texto original: inglês
Generate photorealistic rendering scripts for PyMOL and UCSF ChimeraX.
Idioma do texto original: inglês