ClinicalTrialAgent

Group sequential design methods for interim analyses, alpha spending, and futility stopping. Use when designing trials with interim looks or implementing spending functions.

Core Mediana package functions for Clinical Scenario Evaluation (CSE). Use when designing data models, analysis models, evaluation models, and running comprehensive trial simulations.

Core simtrial package functions for time-to-event clinical trial simulation. Use when generating survival data, performing weighted logrank tests, or running TTE simulations.