菜单
Recommends against using statins in women who are pregnant or trying to become pregnant. Trigger phrases include "Female patient of childbearing potential needing lipid therapy", "Assessing medication safety in pregnancy", "Considering statin for lipid disorder in pregnancy".
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For a person with confirmed islet autoantibodies (early-stage type 1 diabetes), state the numerical progression risk to Stage 3 T1D by stage and age, set the age-stratified monitoring frequency (metabolic and HbA1c), apply the ≥10% longitudinal HbA1c rise → OGTT rule, and give the standard risk-modifier and communication framing. Use when a clinician asks how often should I monitor this Stage 1 child, what's the risk of this teenager progressing to insulin, adult with GAD positive what's the 5-year risk, my patient's HbA1c has risen 12% is that important, single autoantibody how often to retest, or how to counsel a family about progression risk. Grounded in Phillip et al. Diabetologia 2024 international staging and monitoring consensus, cross-referenced with Hussain et al 2026 IDF Europe roadmap.
Order and confirm islet autoantibody screening for early-stage type 1 diabetes — which antibodies to test (GAD65, IAA, IA2, ZnT8), sample types (capillary dried blood spot, venous), the mandatory two-sample two-method confirmation protocol, and how to interpret a positive, negative, or single-antibody result. Use when a clinician asks how to screen for early T1D, which islet autoantibodies to order, how to confirm a positive T1D antibody screen, is one autoantibody enough for T1D diagnosis, GAD antibody positive what next, or is running a general population or family-history T1D screening program. Grounded in Hussain et al 2026 (Diabetes, Obesity and Metabolism, IDF Europe consensus, DOI 10.1111/dom.70569).
Classify a person with a positive islet autoantibody screen into a specific stage of type 1 diabetes (At Risk / Stage 1 / Stage 2a / Stage 2b / Stage 3a / Stage 3b / Stage 4) using the international consensus staging framework based on autoantibody count and glycaemic status. Use when a clinician asks how to stage a positive autoantibody screen, what stage of T1D is this, is this early-stage T1D, does this child need insulin yet, is this presymptomatic T1D, does this qualify for teplizumab, or presents a person with any combination of islet autoantibodies + glucose data. Applies across paediatric and adult populations. Grounded in Hussain et al 2026 (Diabetes, Obesity and Metabolism, IDF Europe consensus, DOI 10.1111/dom.70569).
基于 SOC 职业分类
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| name | endo-statin-contraindication-pregnancy |
| description | Recommends against using statins in women who are pregnant or trying to become pregnant. Trigger phrases include "Female patient of childbearing potential needing lipid therapy", "Assessing medication safety in pregnancy", "Considering statin for lipid disorder in pregnancy". |
Assess pregnancy status, intention to conceive, last menstrual period, and contraceptive use in females of childbearing potential presenting for lipid therapy.
Is the patient pregnant or actively trying to become pregnant? If yes, proceed to Step 4 (avoid statin); if no, proceed to Step 3.
Evaluate lipid-lowering indication per guideline (e.g., LDL‑C >70 mg/dL, ASCVD risk, risk‑enhancing factors) to determine if statin therapy is otherwise indicated.
If pregnant or trying to conceive, do not initiate statin; emphasize lifestyle modification and postpone pharmacologic lipid therapy until after pregnancy. If not pregnant and statin is indicated, initiate appropriate statin therapy.
Do not rely on statins for lipid control in pregnancy due to teratogenic risk (FDA Category X); avoid in lactation unless benefit outweighs risk; do not mistake elevated lipids in pregnancy as requiring statin therapy.
A 32‑year‑old woman with PCOS and LDL‑C 160 mg/dL who is planning pregnancy; statin is withheld, lifestyle changes (diet, exercise) are started, and lipid therapy is reconsidered postpartum.
Source: Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline, Endocrine Society, 2020, doi:10.1210/clinem/dgaa674